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Dipeptidyl-peptidase 6
Protein DPP6 PDB 1xfd.png
PDB rendering based on 1xfd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DPP6 ; DPPX; VF2
External IDs OMIM126141 MGI94921 HomoloGene22560 GeneCards: DPP6 Gene
RNA expression pattern
PBB GE DPP6 207789 s at tn.png
PBB GE DPP6 gnf1h05777 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1804 13483
Ensembl ENSG00000130226 ENSMUSG00000061576
UniProt P42658 Q9Z218
RefSeq (mRNA) NM_001039350 NM_001136060
RefSeq (protein) NP_001034439 NP_001129532
Location (UCSC) Chr 7:
153.58 – 154.69 Mb
Chr 5:
26.82 – 27.73 Mb
PubMed search [1] [2]

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.[1][2]

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


  1. ^ Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S (Feb 1992). "Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family". Proc Natl Acad Sci U S A 89 (1): 197–201. doi:10.1073/pnas.89.1.197. PMC 48203. PMID 1729689. 
  2. ^ a b "Entrez Gene: DPP6 dipeptidyl-peptidase 6". 

Further reading[edit]