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Dipeptidyl-peptidase 8
Symbols DPP8 ; DP8; DPRP1; MSTP141
External IDs OMIM606819 MGI1921638 HomoloGene57098 IUPHAR: 2356 ChEMBL: 4657 GeneCards: DPP8 Gene
EC number
RNA expression pattern
PBB GE DPP8 220939 s at tn.png
More reference expression data
Species Human Mouse
Entrez 54878 74388
Ensembl ENSG00000074603 ENSMUSG00000032393
UniProt Q6V1X1 Q80YA7
RefSeq (mRNA) NM_017743 NM_028906
RefSeq (protein) NP_060213 NP_083182
Location (UCSC) Chr 15:
65.73 – 65.81 Mb
Chr 9:
65.03 – 65.08 Mb
PubMed search [1] [2]

Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.[1][2]

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.[2]


  1. ^ Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD (Nov 2000). "Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8". Eur J Biochem 267 (20): 6140–50. doi:10.1046/j.1432-1327.2000.01617.x. PMID 11012666. 
  2. ^ a b "Entrez Gene: DPP8 dipeptidyl-peptidase 8". 
Further reading