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Dipeptidyl-peptidase 9
Symbols DPP9 ; DP9; DPLP9; DPRP-2; DPRP2
External IDs OMIM608258 MGI2443967 HomoloGene16385 IUPHAR: 2357 ChEMBL: 4793 GeneCards: DPP9 Gene
EC number
Species Human Mouse
Entrez 91039 224897
Ensembl ENSG00000142002 ENSMUSG00000001229
UniProt Q86TI2 Q8BVG4
RefSeq (mRNA) NM_139159 NM_172624
RefSeq (protein) NP_631898 NP_766212
Location (UCSC) Chr 19:
4.68 – 4.72 Mb
Chr 17:
56.19 – 56.22 Mb
PubMed search [1] [2]

Dipeptidyl peptidase 9 is an enzyme that in humans is encoded by the DPP9 gene.[1]

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.[1]


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