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Dihydropyrimidinase-like 2
Protein DPYSL2 PDB 2gse.png
PDB rendering based on 2gse.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DPYSL2 ; CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2
External IDs OMIM602463 MGI1349763 HomoloGene74392 GeneCards: DPYSL2 Gene
RNA expression pattern
PBB GE DPYSL2 200762 at tn.png
More reference expression data
Species Human Mouse
Entrez 1808 12934
Ensembl ENSG00000092964 ENSMUSG00000022048
UniProt Q16555 O08553
RefSeq (mRNA) NM_001197293 NM_009955
RefSeq (protein) NP_001184222 NP_034085
Location (UCSC) Chr 8:
26.37 – 26.52 Mb
Chr 14:
66.8 – 66.87 Mb
PubMed search [1] [2]

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.[1][2]


DPYSL2 has been shown to interact with CRMP1,[3] Adaptor-related protein complex 2, alpha 1[4] and NUMB.[4]


  1. ^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361. 
  2. ^ "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2". 
  3. ^ Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. (Netherlands) 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610. 
  4. ^ a b Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. (England) 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088. 

Further reading[edit]