Prostaglandin D2 receptor

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Prostaglandin D2 receptor (DP)
Identifiers
Symbols PTGDR ; AS1; ASRT1; DP; DP1; PTGDR1
External IDs OMIM604687 MGI102966 HomoloGene736 IUPHAR: DP1 ChEMBL: 4427 GeneCards: PTGDR Gene
RNA expression pattern
PBB GE PTGDR 215894 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5729 19214
Ensembl ENSG00000168229 ENSMUSG00000071489
UniProt Q13258 P70263
RefSeq (mRNA) NM_000953 NM_008962
RefSeq (protein) NP_000944 NP_032988
Location (UCSC) Chr 14:
52.73 – 52.74 Mb
Chr 14:
44.85 – 44.86 Mb
PubMed search [1] [2]

Prostaglandin D2 receptor (DP1) is a G-protein coupled receptor, encoded by the PTGDR gene, for prostaglandin D2.[1]


Mechanism[edit]

DP1 is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.

Function[edit]

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.[1] It also causes vasodilation

See also[edit]

References[edit]

External links[edit]

  • "Prostanoid Receptors: DP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.