DSE (gene)

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Dermatan sulfate epimerase
Identifiers
Symbols DSE ; DSEP; DSEPI; EDSMC2; SART-2; SART2
External IDs OMIM605942 MGI2443455 HomoloGene8354 GeneCards: DSE Gene
EC number 5.1.3.19
RNA expression pattern
PBB GE DSE 218854 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 29940 212898
Ensembl ENSG00000111817 ENSMUSG00000039497
UniProt Q9UL01 Q8BLI4
RefSeq (mRNA) NM_001080976 NM_172508
RefSeq (protein) NP_001074445 NP_766096
Location (UCSC) Chr 6:
116.58 – 116.76 Mb
Chr 10:
34.15 – 34.21 Mb
PubMed search [1] [2]

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.[1][2][3][4][5]

The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene.[3]


References[edit]

  1. ^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (Mar 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522. 
  2. ^ Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A (Apr 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J Biol Chem 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484. 
  3. ^ a b "Entrez Gene: DSE dermatan sulfate epimerase". 
  4. ^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522. 
  5. ^ Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A (April 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J. Biol. Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484. 

Further reading[edit]