DTNA

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Dystrobrevin, alpha
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DTNA ; D18S892E; DRP3; DTN; DTN-A; LVNC1
External IDs OMIM601239 MGI106039 HomoloGene20362 GeneCards: DTNA Gene
RNA expression pattern
PBB GE DTNA 208430 s at tn.png
PBB GE DTNA 210736 x at tn.png
PBB GE DTNA 211493 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1837 13527
Ensembl ENSG00000134769 ENSMUSG00000024302
UniProt Q9Y4J8 Q9D2N4
RefSeq (mRNA) NM_001128175 NM_001285807
RefSeq (protein) NP_001121647 NP_001272736
Location (UCSC) Chr 18:
32.07 – 32.47 Mb
Chr 18:
23.42 – 23.66 Mb
PubMed search [1] [2]

Dystrobrevin alpha is a protein that in humans is encoded by the DTNA gene.[1][2][3]

The protein encoded by this gene belongs to the dystrobrevin subfamily and the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. This protein may be involved in the formation and stability of synapses as well as the clustering of nicotinic acetylcholine receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Interactions[edit]

DTNA has been shown to interact with Dystrophin.[4]

See also[edit]

References[edit]

  1. ^ Khurana TS, Engle EC, Bennett RR, Silverman GA, Selig S, Bruns GA, Kunkel LM (Oct 1994). "(CA) repeat polymorphism in the chromosome 18 encoded dystrophin-like protein". Hum Mol Genet 3 (5): 841. doi:10.1093/hmg/3.5.841-a. PMID 8081380. 
  2. ^ Sjo A, Magnusson KE, Peterson KH (Apr 2005). "Association of alpha-dystrobrevin with reorganizing tight junctions". J Membr Biol 203 (1): 21–30. doi:10.1007/s00232-004-0728-1. PMID 15834686. 
  3. ^ a b "Entrez Gene: DTNA dystrobrevin, alpha". 
  4. ^ Sadoulet-Puccio, H M; Rajala M; Kunkel L M (Nov 1997). "Dystrobrevin and dystrophin: An interaction through coiled-coil motifs". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (23): 12413–8. doi:10.1073/pnas.94.23.12413. ISSN 0027-8424. PMC 24974. PMID 9356463. 

Further reading[edit]