DUSP10

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Dual specificity phosphatase 10
Protein DUSP10 PDB 1zzw.png
PDB rendering based on 1zzw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DUSP10 ; MKP-5; MKP5
External IDs OMIM608867 MGI1927070 HomoloGene5215 GeneCards: DUSP10 Gene
EC number 3.1.3.16, 3.1.3.48
RNA expression pattern
PBB GE DUSP10 221563 at tn.png
PBB GE DUSP10 215501 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11221 63953
Ensembl ENSG00000143507 ENSMUSG00000039384
UniProt Q9Y6W6 Q9ESS0
RefSeq (mRNA) NM_007207 NM_022019
RefSeq (protein) NP_009138 NP_071302
Location (UCSC) Chr 1:
221.87 – 221.92 Mb
Chr 1:
184.01 – 184.08 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.[1][2][3]

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.[3]

Interactions[edit]

DUSP10 has been shown to interact with MAPK14[4][5][6] and MAPK8.[1]

References[edit]

  1. ^ a b Tanoue T, Moriguchi T, Nishida E (Aug 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J Biol Chem 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. PMID 10391943. 
  2. ^ Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A (Jan 2000). "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases". Oncogene 18 (50): 6981–8. doi:10.1038/sj.onc.1203185. PMID 10597297. 
  3. ^ a b "Entrez Gene: DUSP10 dual specificity phosphatase 10". 
  4. ^ Tanoue, T; Moriguchi T; Nishida E (Jul 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. (UNITED STATES) 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943. 
  5. ^ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. (United States) 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773. 
  6. ^ Tanoue, T; Maeda R; Adachi M; Nishida E (Feb 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. (England) 20 (3): 466–79. doi:10.1093/emboj/20.3.466. ISSN 0261-4189. PMC 133461. PMID 11157753. 

Further reading[edit]