From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dual specificity phosphatase 12
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DUSP12 ; DUSP1; YVH1
External IDs OMIM604835 MGI1890614 HomoloGene5238 GeneCards: DUSP12 Gene
EC number,
RNA expression pattern
PBB GE DUSP12 218576 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11266 80915
Ensembl ENSG00000081721 ENSMUSG00000026659
UniProt Q9UNI6 Q9D0T2
RefSeq (mRNA) NM_007240 NM_023173
RefSeq (protein) NP_009171 NP_075662
Location (UCSC) Chr 1:
161.72 – 161.73 Mb
Chr 1:
170.87 – 170.89 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.[1][2]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.[2]


  1. ^ Muda M, Manning ER, Orth K, Dixon JE (Sep 1999). "Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function". J Biol Chem 274 (34): 23991–5. doi:10.1074/jbc.274.34.23991. PMID 10446167. 
  2. ^ a b "Entrez Gene: DUSP12 dual specificity phosphatase 12". 

Further reading[edit]