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Dual specificity phosphatase 15
Protein DUSP15 PDB 1yz4.png
PDB rendering based on 1yz4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DUSP15 ; VHY
External IDs MGI1934928 HomoloGene33586 GeneCards: DUSP15 Gene
EC number,
Species Human Mouse
Entrez 128853 252864
Ensembl ENSG00000149599 ENSMUSG00000042662
UniProt Q9H1R2 Q8R4V2
RefSeq (mRNA) NM_001012644 NM_001159376
RefSeq (protein) NP_001012662 NP_001152848
Location (UCSC) Chr 20:
30.44 – 30.46 Mb
Chr 2:
152.94 – 152.95 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene.[1][2]

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants, encoding two different isoforms have been found for this gene.[2]


  1. ^ Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H, Williams S, Gjorloff-Wingren A, Bremer MC, Holsinger LJ, Millan JL, Mustelin T (Jul 2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX". J Biol Chem 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252. 
  2. ^ a b "Entrez Gene: DUSP15 dual specificity phosphatase 15". 

Further reading[edit]