DUSP16

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Dual specificity phosphatase 16
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DUSP16 ; MKP-7; MKP7
External IDs OMIM607175 MGI1917936 HomoloGene15604 GeneCards: DUSP16 Gene
EC number 3.1.3.16, 3.1.3.48
Orthologs
Species Human Mouse
Entrez 80824 70686
Ensembl ENSG00000111266 ENSMUSG00000030203
UniProt Q9BY84 E9PV17
RefSeq (mRNA) NM_030640 NM_001048054
RefSeq (protein) NP_085143 NP_001041519
Location (UCSC) Chr 12:
12.63 – 12.72 Mb
Chr 6:
134.72 – 134.79 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.[1][2][3][4]

The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM][4]

Interactions[edit]

DUSP16 has been shown to interact with MAPK14[5][6] and MAPK8IP1.[7]

References[edit]

  1. ^ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J Biol Chem 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773. 
  2. ^ Masuda K, Shima H, Watanabe M, Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J Biol Chem 276 (42): 39002–11. doi:10.1074/jbc.M104600200. PMID 11489891. 
  3. ^ Willoughby EA, Collins MK (Jul 2005). "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2". J Biol Chem 280 (27): 25651–8. doi:10.1074/jbc.M501926200. PMID 15888437. 
  4. ^ a b "Entrez Gene: DUSP16 dual specificity phosphatase 16". 
  5. ^ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. (United States) 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773. 
  6. ^ Masuda, K; Shima H; Watanabe M; Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J. Biol. Chem. (United States) 276 (42): 39002–11. doi:10.1074/jbc.M104600200. ISSN 0021-9258. PMID 11489891. 
  7. ^ Willoughby, Emma A; Perkins Gordon R; Collins Mary K; Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. (United States) 278 (12): 10731–6. doi:10.1074/jbc.M207324200. ISSN 0021-9258. PMID 12524447. 

Further reading[edit]