DUSP19

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Dual specificity phosphatase 19
3s4eskrp1.png
Mitogen-activated Protein Kinase Phosphatase, SKRP1. PDB 3s4e[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DUSP19 ; DUSP17; LMWDSP3; SKRP1; TS-DSP1
External IDs OMIM611437 MGI1915332 HomoloGene41565 GeneCards: DUSP19 Gene
EC number 3.1.3.16, 3.1.3.48
RNA expression pattern
PBB GE DUSP19 gnf1h03972 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 142679 68082
Ensembl ENSG00000162999 ENSMUSG00000027001
UniProt Q8WTR2 n/a
RefSeq (mRNA) NM_001142314 NM_024438
RefSeq (protein) NP_001135786 NP_077758
Location (UCSC) Chr 2:
183.94 – 183.96 Mb
Chr 2:
80.62 – 80.63 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.[2]


Interactions[edit]

DUSP19 has been shown to interact with ASK1[3] and MAP2K7.[3][4]

References[edit]

  1. ^ Wei, C. H.; Ryu, S. Y.; Jeon, Y. H.; Yoon, M. Y.; Jeong, D. G.; Kim, S. J.; Ryu, S. E. (2011). "Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1". Proteins: Structure, Function, and Bioinformatics 79 (11): 3242–3246. doi:10.1002/prot.23156. PMID 21989941.  edit
  2. ^ "Entrez Gene: DUSP19 dual specificity phosphatase 19". 
  3. ^ a b Zama, Takeru; Aoki Ryoko; Kamimoto Takahiro; Inoue Koichi; Ikeda Yasuo; Hagiwara Masatoshi (Jun 2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". J. Biol. Chem. (United States) 277 (26): 23919–26. doi:10.1074/jbc.M200838200. ISSN 0021-9258. PMID 11959862. 
  4. ^ Zama, Takeru; Aoki Ryoko; Kamimoto Takahiro; Inoue Koichi; Ikeda Yasuo; Hagiwara Masatoshi (Jun 2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway". J. Biol. Chem. (United States) 277 (26): 23909–18. doi:10.1074/jbc.M200837200. ISSN 0021-9258. PMID 11959861. 

Further reading[edit]