From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dual specificity phosphatase 2
Protein DUSP2 PDB 1m3g.png
PDB rendering based on 1m3g.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DUSP2 ; PAC-1; PAC1
External IDs OMIM603068 MGI101911 HomoloGene3255 GeneCards: DUSP2 Gene
EC number,
RNA expression pattern
PBB GE DUSP2 204794 at tn.png
More reference expression data
Species Human Mouse
Entrez 1844 13537
Ensembl ENSG00000158050 ENSMUSG00000027368
UniProt Q05923 Q05922
RefSeq (mRNA) NM_004418 NM_010090
RefSeq (protein) NP_004409 NP_034220
Location (UCSC) Chr 2:
96.81 – 96.81 Mb
Chr 2:
127.34 – 127.34 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene.[1][2][3][4]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.[4]


  1. ^ Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM (Jan 1995). "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases". Genomics 22 (2): 462–4. doi:10.1006/geno.1994.1411. PMID 7806236. 
  2. ^ Yi H, Morton CC, Weremowicz S, McBride OW, Kelly K (Dec 1995). "Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11". Genomics 28 (1): 92–6. doi:10.1006/geno.1995.1110. PMID 7590752. 
  3. ^ Yin Y, Liu YX, Jin YJ, Hall EJ, Barrett JC (Apr 2003). "PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression". Nature 422 (6931): 527–31. doi:10.1038/nature01519. PMID 12673251. 
  4. ^ a b "Entrez Gene: DUSP2 dual specificity phosphatase 2". 

Further reading[edit]