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Dual specificity phosphatase 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DUSP4 ; HVH2; MKP-2; MKP2; TYP
External IDs OMIM602747 MGI2442191 HomoloGene1065 GeneCards: DUSP4 Gene
EC number,
RNA expression pattern
PBB GE DUSP4 204015 s at tn.png
PBB GE DUSP4 204014 at tn.png
More reference expression data
Species Human Mouse
Entrez 1846 319520
Ensembl ENSG00000120875 ENSMUSG00000031530
UniProt Q13115 Q8BFV3
RefSeq (mRNA) NM_001394 NM_176933
RefSeq (protein) NP_001385 NP_795907
Location (UCSC) Chr 8:
29.19 – 29.21 Mb
Chr 8:
34.81 – 34.82 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.[1][2][3]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.[3]

In melanocytic cells DUSP4 gene expression may be regulated by MITF.[4]


  1. ^ Guan KL, Butch E (May 1995). "Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase". J Biol Chem 270 (13): 7197–203. doi:10.1074/jbc.270.13.7197. PMID 7535768. 
  2. ^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Sep 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128. 
  3. ^ a b "Entrez Gene: DUSP4 dual specificity phosphatase 4". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

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