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Dual specificity phosphatase 5
Protein DUSP5 PDB 2g6z.png
PDB rendering based on 2g6z.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DUSP5 ; DUSP; HVH3
External IDs OMIM603069 MGI2685183 HomoloGene3256 ChEMBL: 1250380 GeneCards: DUSP5 Gene
EC number,
RNA expression pattern
PBB GE DUSP5 209457 at tn.png
More reference expression data
Species Human Mouse
Entrez 1847 240672
Ensembl ENSG00000138166 ENSMUSG00000034765
UniProt Q16690 Q1HL35
RefSeq (mRNA) NM_004419 NM_001085390
RefSeq (protein) NP_004410 NP_001078859
Location (UCSC) Chr 10:
112.26 – 112.27 Mb
Chr 19:
53.53 – 53.54 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.[1][2]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1/2, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.[2]


  1. ^ Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM (Jan 1995). "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases". Genomics 22 (2): 462–4. doi:10.1006/geno.1994.1411. PMID 7806236. 
  2. ^ a b "Entrez Gene: DUSP5 dual specificity phosphatase 5". 

Further reading[edit]