DUSP6

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Dual specificity phosphatase 6
Protein DUSP6 PDB 1hzm.png
PDB rendering based on 1hzm.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DUSP6 ; HH19; MKP3; PYST1
External IDs OMIM602748 MGI1914853 HomoloGene55621 ChEMBL: 1250381 GeneCards: DUSP6 Gene
EC number 3.1.3.16, 3.1.3.48
RNA expression pattern
PBB GE DUSP6 208892 s at tn.png
PBB GE DUSP6 208891 at tn.png
PBB GE DUSP6 208893 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1848 67603
Ensembl ENSG00000139318 ENSMUSG00000019960
UniProt Q16828 Q9DBB1
RefSeq (mRNA) NM_001946 NM_026268
RefSeq (protein) NP_001937 NP_080544
Location (UCSC) Chr 12:
89.74 – 89.75 Mb
Chr 10:
99.26 – 99.27 Mb
PubMed search [1] [2]

Dual specificity phosphatase 6, also known as DUSP6, is an enzyme that in humans is encoded by the DUSP6 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.[1]

Interactions[edit]

DUSP6 has been shown to interact with MAPK3.[4]

References[edit]

  1. ^ a b "Entrez Gene: DUSP6 dual specificity phosphatase 6". 
  2. ^ Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S (February 1996). "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". J. Biol. Chem. 271 (8): 4319–26. doi:10.1074/jbc.271.8.4319. PMID 8626780. 
  3. ^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (June 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128. 
  4. ^ Muda, M; Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodrigues N, Davies K, Ashworth A, Arkinstall S (Apr 1998). "The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity". J. Biol. Chem. (UNITED STATES) 273 (15): 9323–9. doi:10.1074/jbc.273.15.9323. ISSN 0021-9258. PMID 9535927. 

Further reading[edit]