DUSP7

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Dual specificity phosphatase 7
Identifiers
Symbols DUSP7 ; MKPX; PYST2
External IDs OMIM602749 MGI2387100 HomoloGene1468 GeneCards: DUSP7 Gene
EC number 3.1.3.16, 3.1.3.48
RNA expression pattern
PBB GE DUSP7 213848 at tn.png
PBB GE DUSP7 214793 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1849 235584
Ensembl ENSG00000164086 ENSMUSG00000053716
UniProt Q16829 Q91Z46
RefSeq (mRNA) NM_001947 NM_153459
RefSeq (protein) NP_001938 NP_703189
Location (UCSC) Chr 3:
52.08 – 52.09 Mb
Chr 9:
106.37 – 106.38 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.[1][2][3]

Function[edit]

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to de-phosphorylate both tyrosine (EC 3.1.3.48) and serine / threonine (EC 3.1.3.16) residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses.[3][4]

It is known to bind and dephosphorylate ErkII, and as it, along with the other members of the DUSP family expresses high selectively for MAP kinases, it has been suggested that it functions as a method for selectively activating/deactivating different members of that family.[5]

References[edit]

  1. ^ Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S (Jun 1996). "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". J Biol Chem 271 (8): 4319–26. doi:10.1074/jbc.271.8.4319. PMID 8626780. 
  2. ^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Sep 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128. 
  3. ^ a b "Entrez Gene: DUSP7 dual specificity phosphatase 7". 
  4. ^ Patterson KI, Brummer T, O'Brien PM, Daly RJ (March 2009). "Dual-specificity phosphatases: critical regulators with diverse cellular targets". Biochem. J. 418 (3): 475–89. PMID 19228121. 
  5. ^ Dowd S, Sneddon AA, Keyse SM (November 1998). "Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases". J. Cell. Sci. 111 (22): 3389–99. PMID 9788880. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.