DUT (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
For generic Dutpase entry, see DUTP_diphosphatase.
Deoxyuridine triphosphatase
Protein DUT PDB 1q5h.png
PDB rendering based on 1q5h.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DUT ; dUTPase
External IDs OMIM601266 MGI1346051 HomoloGene31475 ChEMBL: 5203 GeneCards: DUT Gene
EC number 3.6.1.23
RNA expression pattern
PBB GE DUT 208955 at tn.png
PBB GE DUT 208956 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1854 110074
Ensembl ENSG00000128951 ENSMUSG00000027203
UniProt P33316 Q8VCG1
RefSeq (mRNA) NM_001025248 NM_001159646
RefSeq (protein) NP_001020419 NP_001153118
Location (UCSC) Chr 15:
48.62 – 48.64 Mb
Chr 2:
125.25 – 125.26 Mb
PubMed search [1] [2]

DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene.[1]

Function[edit]

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotrimeric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.[1]

References[edit]

Further reading[edit]