From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dishevelled segment polarity protein 2
Protein DVL2 PDB 1l6o.png
PDB rendering based on 1l6o.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol DVL2
External IDs OMIM602151 MGI106613 HomoloGene20927 ChEMBL: 1255125 GeneCards: DVL2 Gene
RNA expression pattern
PBB GE DVL2 57532 at tn.png
PBB GE DVL2 218759 at tn.png
More reference expression data
Species Human Mouse
Entrez 1856 13543
Ensembl ENSG00000004975 ENSMUSG00000020888
UniProt O14641 Q60838
RefSeq (mRNA) NM_004422 NM_007888
RefSeq (protein) NP_004413 NP_031914
Location (UCSC) Chr 17:
7.13 – 7.14 Mb
Chr 11:
70 – 70.01 Mb
PubMed search [1] [2]

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.[1][2]

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.[2]


DVL2 has been shown to interact with Zinc finger protein 165,[3] DAB2[4] and Arrestin beta 1.[5]

See also[edit]


  1. ^ Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242. 
  2. ^ a b "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)". 
  3. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. (England) 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222. 
  5. ^ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (26): 14889–94. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073. 

Further reading[edit]