From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dishevelled, dsh homolog 3 (Drosophila)
Protein DVL3 PDB 1l6o.png
PDB rendering based on 1l6o.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DVL3 ; KIAA0208
External IDs OMIM601368 MGI108100 HomoloGene20928 ChEMBL: 6028 GeneCards: DVL3 Gene
RNA expression pattern
PBB GE DVL3 201908 at tn.png
More reference expression data
Species Human Mouse
Entrez 1857 13544
Ensembl ENSG00000161202 ENSMUSG00000003233
UniProt Q92997 Q61062
RefSeq (mRNA) NM_004423 NM_007889
RefSeq (protein) NP_004414 NP_031915
Location (UCSC) Chr 3:
183.87 – 183.89 Mb
Chr 16:
20.52 – 20.53 Mb
PubMed search [1] [2]

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.[1][2]

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.[2]


DVL3 has been shown to interact with DAB2,[3] DVL1[4] and PRPF3.[5]

See also[edit]


  1. ^ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329. 
  2. ^ a b "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)". 
  3. ^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. (England) 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222. 
  4. ^ Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4414–22. ISSN 0270-7306. PMC 104400. PMID 10330181. 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]