Her breakthrough in the U.S. came in 1993, when her quintessential photographs of residents in the Watts section of Los Angeles, published in Vrij Nederland, caught the attention of New York's Vibe magazine.
Lixenberg’s trademark is a 4x5 camera and tripod. She enjoys illustrating contrast in her work and portraying people in pure form. Lixenberg photographs people from all social classes, as her 2001 book United States illustrates. In addition to ordinary people, Lixenberg has photographed a number of American celebrities, including Prince and Whitney Houston.
Lixenberg is also a film director and directed the Dutch singer Anouk’s 2005 video ‘One Word’.