Daniel Kraft, M.D. is an NIH funded faculty member affiliated with Stanford. He was on clinical faculty with the UCSF pediatric bone marrow transplantation service and serves as the medicine track chair for Singularity University where he is also executive director for the FutureMed executive program.
Daniel is the founder of StemCor Systems and founder and consulting chief medical officer for RegenMed Systems, a clinical-stage medical device company that develops tools to enable regenerative stem cell therapies. He is the inventor of the MarrowMiner, a minimally invasive device for the harvest of bone marrow derived stem and progenitor cells. This device is being commercialized by Hospira Inc. for use in bone marrow transplantation and by RegenMed Systems for use in regenerative medicine.
Dr. Kraft received a degree in Biochemistry from Brown University and his M.D. from the Stanford University School of Medicine. He completed the Harvard combined residency in Internal Medicine and Pediatrics at the Massachusetts General Hospital and the Boston Children's Hospital, before returning to Stanford for clinical fellowship training in hematology/oncology and bone marrow transplantation and a post-doctoral fellowship with Dr. Irving Weissman. Dr. Kraft is board certified in both Pediatrics and Internal Medicine.
In addition to his research and scientific papers, Dr. Kraft has spoken publicly on, performed research into, and consulted on: health data, health statistics, personalized medicine, heath decision making, the future of medicine, and emerging medical technologies.
As part of his early research at the National Institutes of Health, Dr. Kraft conceived of and demonstrated proof of concept for a monoclonal antibody-based therapy for treating allergic disease; his general approach was later translated to an antibody Xolair therapeutic by Genentech. As a Howard Hughes Medical Institute medical student research fellow at Stanford, he discovered at novel population of developing T-cells, which play a role in HIV infection. His research focuses extensively on stem cell biology, immunology, and regenerative medicine.
Dr. Kraft's research focuses on: stem cell biology and regenerative medicine, stem cell derived immunotherapies for cancer, bioengineering, the hematopoietic stem cell niche in murine and human systems, human T-cell differentiation, and humanized animal models. Dr. Kraft's clinical work focuses on: bone marrow / hematopoietic Stem cell transplantation for malignant and non-malignant diseases in adults & children, medical devices to enable stem cell based regenerative medicine, including marrow derived stem cell harvesting, processing and delivery.
Dr. Kraft built the first Internet-based alphanumeric paging system at the Stanford hospitals to facilitate communication between clinical staff, and later for elements of Stanford internal medicine and bone marrow transplant service.
In addition to his research at and in connection with Stanford University, Dr. Kraft has performed research into and consulting on health data, health statistics, personalized medicine and heath decision making, including work as an adviser to CollabRx (personalized oncology), Wellsphere (health and wellness) (acquired by HealthCentral), Cepheid (point of care diagnostics), and to the X-Prize Foundation.
Daniel Kraft has scientific publications to his credit, including several in Science and Nature. He has lectured extensively on stem cell biology and regenerative medicine, and has authored several book chapters.
Publications include the following articles:
- Chan, Charles K. F.; Chen, Ching-Cheng; Luppen, Cynthia A.; Kim, Jae-Beom; Deboer, Anthony T.; Wei, Kevin; Helms, Jill A.; Kuo, Calvin J. et al. (2008). "Endochondral ossification is required for haematopoietic stem-cell niche formation". Nature 457 (7228): 490–4. doi:10.1038/nature07547. PMC 2648141. PMID 19078959.
- Czechowicz, A.; Kraft, D.; Weissman, I. L.; Bhattacharya, D. (2007). "Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches". Science 318 (5854): 1296–9. doi:10.1126/science.1149726. PMC 2527021. PMID 18033883.
- Li, Zongjin; Wilson, Kitchener D.; Smith, Bryan; Kraft, Daniel L.; Jia, Fangjun; Huang, Mei; Xie, Xiaoyan; Robbins, Robert C. et al. (2009). "Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction". In Capogrossi, Maurizio C. PLoS ONE 4 (12): e8443. doi:10.1371/journal.pone.0008443. PMC 2795856. PMID 20046878.
- Kraft, D.; Crocker, M.; Ramella, O.; Ghazarossian, V.; Carrasco Yalan, A. (2009). "The "Marrowminer", A Novel, Minimally Invasive Device for the Harvest of Bone Marrow: Results from the Marvelous Trial Demonstrate Safety, Efficacy and Improved Stem Cell Yields Compared to Standard Marrow Harvest Method". Biology of Blood and Marrow Transplantation 15 (2): 18. doi:10.1016/j.bbmt.2008.12.052.
- Hongo, D; Hadidi, S; Damrauer, S; Garrigue, V; Kraft, D; Sachs, DH; Nikolic, B; Sykes, M (2007). "Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction". The Journal of infectious diseases 196 (6): 900–10. doi:10.1086/520516. PMID 17703422.
- Li, Z.; Wu, J. C.; Sheikh, A. Y.; Kraft, D.; Cao, F.; Xie, X.; Patel, M.; Gambhir, S. S. et al. (2007). "Differentiation, Survival, and Function of Embryonic Stem Cell Derived Endothelial Cells for Ischemic Heart Disease". Circulation 116 (11_suppl): I–46. doi:10.1161/CIRCULATIONAHA.106.680561.
- Kraft, Daniel L.; Weissman, Irving L. (2005). "Hematopoietic Stem Cells: Basic Science to Clinical Applications". In Bongso, Ariff; Lee, Eng Hin. Stem Cells: From Bench to Bedside. Singapore: World Scientific. ISBN 978-981-256-937-0.
- Soen, Yoav; Chen, Daniel S.; Kraft, Daniel L.; Davis, Mark M.; Brown, Patrick O. (2003). "Detection and Characterization of Cellular Immune Responses Using Peptide–MHC Microarrays". PLoS Biology 1 (3): e5. doi:10.1371/journal.pbio.0000065.
- Lindgren, KN; Kraft, D; Ballard, RE; Tucker, A; Hargens, AR (1998). "Venoconstrictive thigh cuffs impede fluid shifts during simulated microgravity". Aviation, space, and environmental medicine 69 (11): 1052–8. PMID 9819160.
- Su, L; Kaneshima, H; Bonyhadi, M; Salimi, S; Kraft, D; Rabin, L; McCune, JM (1995). "HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo". Immunity 2 (1): 25–36. doi:10.1016/1074-7613(95)90076-4. PMID 7600300.
- Kraft, DL; Weissman, IL; Waller, EK (1993). "Differentiation of CD3-4-8- human fetal thymocytes in vivo: Characterization of a CD3-4+8- intermediate". The Journal of experimental medicine 178 (1): 265–77. PMC 2191096. PMID 8315382.
- Kitani, S; Kraft, D; Fischler, C; Mergenhagen, SE; Siraganian, RP (1988). "Inhibition of allergic reactions with monoclonal antibody to the high affinity IgE receptor". Journal of immunology (Baltimore, Md. : 1950) 140 (8): 2585–8. PMID 2451693.
Dr. Kraft has research and clinical expertise in aerospace medicine.
He is a Major in the Air National Guard and serves as flight surgeon, originally with an F-15 squadron in the Massachusetts Air National Guard and currently with an F-16 squadron in the 144th Fighter Wing, California Air National Guard, with whom he has deployed to Nicaragua and Saudi Arabia.
Dr. Kraft has presented talks at a number of venues which have been recorded and are available online including two TEDTalks. Dr. Kraft's talks include presentations at the TED and 2009 & 2011 TEDMED conferences, Singularity University, the Web 2.0 summit, and the 2009 Keynote Address at the USC Body Computing Conference.
Talks and panel discussions include: "TEDTalk - Medicine's Future", "Hype, Hope & Reality in Stem Cells and Regenerative Medicine", "The Future of Medicine", "The Future of Health", and "The Convergence of Life Sciences, Medicine and Exponentially Advancing Life Technologies."  and a TED presentation on the Marrow Miner, a minimally invasive bone marrow and adult stem cell harvesting device invented by Dr. Kraft.
- Adviser to the X Prize Foundation (Life Sciences)
- Adviser to CollabRx (Personalized Oncology)
- Adviser to Wellsphere (general health and wellness)
- Adviser to Cepheid (point of care diagnostics)
- Adviser to Lunar Design
While a resident at Harvard, Dr. Kraft founded, developed, and operated the Online Medical Bookstore (later acquired by Netivation), one of the first online marketplaces for medical students and professionals.
Dr. Kraft is a founder of StemCor Systems.
- Adaptive Business Leaders 2011 "Leadership in Innovation" Awardee & Keynote speaker:
- Young Investigator Award, American Society for Bone Marrow Transplantation (ASBMT) (2008)
- Research Award, Hope Street Kids Foundation (2006)
- Clinical Scientist Developmental Award (K-08), NHLBI/NIH (2005)
- Astronaut selection finalist (Mission Specialist), NASA (2004)
- National Innovation grant: National Collegiate Inventors and Innovators Alliance, NCIIA (2003)
- United States Air Force Meritorious Achievement Medal (2000)
- Research Fellowship, Pediatric Scientist Development Program (PSDP)
- Innovation Grant, National Collegiate Inventors & Innovators Alliance (NCIIA)
- Dean's Award for Research, Stanford Medical School
- HHMI Research Training Fellowship, Howard Hughes Medical Institute
- Stanford School of Medicine
- FutureMed Executive Program
- RegenMed Systems
- Longhurst C. , Kraft D. Internet-Based Alphanumeric Paging: A Useful Tool for Rapid, Convenient and Effective Intrahospital Communication. American Acad of Pediatrics 2002 National Conference & Exhibition. 2002: Abstract 1:707
- Search Results for author Kraft D on PubMed.
- Stanford Report: High-flying fellow divides his time between stem cell research and guard duties as a flight surgeon
- TEDTalk: Medicine's Future...
- TEDMED Talk: Hype, Hope & Reality in Stem Cells and Regenerative Medicine
- Singularity University Talk: The Future of Medicine
- Web 2.0 Summit Panel: The Future of Health (With Marc Hodosh, Anne Wojcicki, Carol McCall, and Daniel Kraft
- Keynote Address, USC Body Computing Conference: The Convergence of Life Sciences, Medicine and Exponentially Advancing Life Technologies
- TED Presentation on the 'MarrowMiner' bone marrow extraction device
- X Prize Foundation Website
- CollabRx Website
- Wellsphere Website
- Cephid Website
- Lunar Design Website
- Carlson, Robert H. (2009). "Quicker Bone Marrow Collection with 'MarrowMiner' Device". Oncology Times 31 (20): 29–31. doi:10.1097/01.COT.0000363662.09960.e9.
- Singularity University
- Adaptive Business Leaders “Leadership in Innovation"