His first instrument was the flute, which he played at the San Pietro a Majella conservatoire. After graduating, he began performing with the Gruppo operaio 'E Zezi di Pomigliano d'Arco, playing at numerous festivals and recording a few albums.
Sepe soon, however, became more interested in jazz and learned to play the saxophone. He continued recording and began performing with many prominent musicians, like Nino D'Angelo, Gino Paoli, Eduardo de Crescenzo, Mia Martini, Teresa de Sio, Roberto de Simone, Peppino Gagliardi, Nino Bonocore and Roberto Murolo. His band, which played under several names, varied widely, from purely wind instruments to big bands. He also composed music for the theatre, cinema and ballet.
In 1994, Sepe recorded Vite Perdite, which was much more successful than any of his previous niche recordings. It was dubbed album of year by Rockerilla, one of the one hundred greatest albums of the 1990s by Rockstar, and received a rave review from Folk-Roots, an English magazine.
|1992||L'uscita dei gladiatori||Stile Libero/Virgin|
|1993||Play Standard and More||Officina|
|1994||Vite perdite||Polo Sud-Piranha|
|1996||Viaggi fuori dai paraggi (compilation)||Il Manifesto|
|1997||Spiritus Mundi||Polo sud|
|1997||L'uscita dei gladiatori - rivisto e corretto||Il Manifesto|
|1999||Toto sketches||Polo Sud|
|2000||Conosci Víctor Jara?||Il Manifesto|
|2000||Viaggi Fuori Dai Paraggi||Robi Droli/Newtone|
|2004||Truffe & Other Sturiellett' Vol. 1||Polo Sud|
|2004||Truffe & other sturiellett' Vol 2||Polo Sud|
|2004||Nia Maro||Il Manifesto|
|2005||Lesamore (con A.Kokko)||Materiali Sonori|
|2005||Una Bandi di Pezzenti||RaiTrade|
|2006||Suonarne 1 per educarne 100|
|2008||Nostra patria è il mondo intero con la Brigada Internazionale|