Trussoni was born in La Crosse, Wisconsin, and was named after her father Daniel Trussoni. She is one of four children (she has a younger sister, a younger brother and an older sister who was adopted out in 1970, before Danielle was born). Danielle met her older sister for the first time as an adult. After her parents divorced, she lived for a brief time with her father. She graduated from the University of Wisconsin–Madisonsumma cum laude with a BA in History and English in 1996; and from the Iowa Writers' Workshop, where she received an MFA in Fiction Writing in 2002.
Her novel Angelology, (Viking Press, 2010) received a great deal of attention prior to publication. Seven publishing houses vied for the publishing rights. Angelology went on to become a New York Times Bestseller and has been translated into thirty-two languages. Two motion picture companies, Columbia and Universal, bid for the film rights, which went to Columbia. The film will be produced by Will Smith's Overbrook production company and directed by Marc Forster, director of Finding Neverland and Quantum of Solace, among other films. The screenplay has been adapted by Michael Goldenberg, whose work includes Harry Potter and the Order of the Phoenix and Where the Wild Things Are. Trussoni is planning a series and the second book, Angelopolis, is due out March 26, 2013.