The Darling Mills Creek takes its name from a watermill constructed a short distance from the confluence with Toongabbie Creek.
An earlier watermill was built by Samuel Marsden near the confluence. It milled flour from 1804 to 1818.
In 1825, the Darling Flour Mills were built for John Raine, upstream on the Windsor Road.
The Darling Mills site was taken over by Sydney Woollen Mills, which operated from 1870 to 1975. Sydney Woollen Mills originally used steam rather than water power. Part of the facade of the building remains on the site, which is now occupied by Bunnings Warehouse's North Parramatta store. There is a weir on the creek nearby that was constructed in the nineteenth century.