David Eisenberg

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David Eisenberg
David Eisenberg - journal.pcbi.1003116.g001.png
David Eisenberg
Born (1939-03-15) March 15, 1939 (age 75)[citation needed]
Chicago, United States
Fields Proteins[1]
Amyloid[2]
Structural biology[3][4][5]
Institutions Howard Hughes Medical Institute
University of Oxford
University of California, Los Angeles
Harvard University
California Institute of Technology
Princeton University
Alma mater Harvard University (undergraduate)
The Queen's College, Oxford (postgraduate)
Thesis Some problems in the electronic structure of molecules (1965)
Doctoral advisor Charles Coulson[citation needed]
Doctoral students Michael Gribskov[citation needed]
Notable awards Harvey Prize (2008)
ISCB Senior Scientist Award (2013)[6]
Website
www.doe-mbi.ucla.edu/People/Eisenberg
www.hhmi.org/research/investigators/eisenberg_bio.html

David S. Eisenberg (born 15 March 1939) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology. A professor at the University of California, Los Angeles since the early 1970s and director of the UCLA-DOE Institute for Genomics & Proteomics since the early 1990s, as well as a member of the California NanoSystems Institute (CNSI) at UCLA.[7][8][9][10][11][12][13]

Education[edit]

Eisenberg was educated at Harvard University graduating in 1961. He went on to the University of Oxford, where he was awarded a D.Phil in 1965[14] for research supervised by Charles Coulson.

Research[edit]

Eisenberg's current research focuses on the structural biology of amyloidogenic proteins, while his computational efforts largely center on the development of bioinformatic/proteomic methodologies for elucidation and analysis of protein interaction networks. His research group hosts the Database of Interacting Proteins.[15]

Career[edit]

  • Postdoctoral research, Princeton University (1964–1966; with Walter Kauzmann)
  • Postdoctoral research, California Institute of Technology (1966–1969; with Richard E. Dickerson)
  • Professor, Department of Chemistry & Biochemistry, UCLA, USA (1969–Present)
  • Professor, Department of Biological Chemistry, UCLA Medical School
  • Director, UCLA-DOE Institute for Genomics & Proteomics (1993–Present)
  • Member, California NanoSystems Institute (CNSI), UCLA
  • Investigator, Howard Hughes Medical Institute (2001–Present)

Awards[edit]

He was the recipient of Harvey Prize (Human Health) 2008 in recognition of his contributions in unfolding the structure of amyloid fibrils. The award was presented to him at a ceremony that took place on March 23, 2009 at the Technion. This recently recognized protein state provides opportunities to understand cells in health and disease.[16]

References[edit]

  1. ^ Eisenberg, D.; McLachlan, A. D. (1986). "Solvation energy in protein folding and binding". Nature 319 (6050): 199–203. doi:10.1038/319199a0. PMID 3945310.  edit
  2. ^ Balbirnie, M.; Grothe, R.; Eisenberg, D. S. (2001). "An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta -sheet structure for amyloid". Proceedings of the National Academy of Sciences 98 (5): 2375–2380. doi:10.1073/pnas.041617698. PMC 30146. PMID 11226247.  edit
  3. ^ Lüthy, R.; Bowie, J. U.; Eisenberg, D. (1992). "Assessment of protein models with three-dimensional profiles". Nature 356 (6364): 83–85. doi:10.1038/356083a0. PMID 1538787.  edit
  4. ^ Chapman, M. S.; Suh, S. W.; Curmi, P. M.; Cascio, D.; Smith, W. W.; Eisenberg, D. S. (1988). "Tertiary structure of plant RuBisCO: Domains and their contacts". Science 241 (4861): 71–74. doi:10.1126/science.3133767. PMID 3133767.  edit
  5. ^ List of publications from Google Scholar
  6. ^ Fogg, C. N.; Kovats, D. E. (2013). "International Society for Computational Biology Honors David Eisenberg with 2013 Accomplishment by a Senior Scientist Award". PLoS Computational Biology 9 (6): e1003116. doi:10.1371/journal.pcbi.1003116. PMC 3681620. PMID 23785275.  edit
  7. ^ HHMI profile of David Eisenberg
  8. ^ The Eisenberg research lab at UCLA
  9. ^ UCLA-DOE Institute for Genomics & Proteomics
  10. ^ David Eisenberg’s speech during the Harvey Prize ceremony
  11. ^ Eisenberg, David; Kauzmann, Walter (2005). The structure and properties of water. Oxford: Clarendon Press. ISBN 0-19-857026-0. 
  12. ^ List of publications from Microsoft Academic Search
  13. ^ David Eisenberg from the Scopus bibliographic database
  14. ^ Eisenberg, David J. (1965). Some problems in the electronic structure of molecules (PhD thesis). University of Oxford. 
  15. ^ Salwinski, L.; Miller, C. S.; Smith, A. J.; Pettit, F. K.; Bowie, J. U.; Eisenberg, D. (2004). "The Database of Interacting Proteins: 2004 update". Nucleic Acids Research 32 (90001): D449–D451. doi:10.1093/nar/gkh086. PMC 308820. PMID 14681454.  edit
  16. ^ Harvey Prize Award