Fane got into acting quite late and trained at the New Zealand Drama School Toi Whakaari, graduating in 1991. He first appeared on television in a sketch comedy show called SKITZ alongside future Naked SamoansOscar Kightley and Robbie Magasiva. He then did the sitcom spinoff "the semisis" in which he played the father and the minister. The play won the 2004 Chapman Tripp Theatre Award for Outstanding New Zealand Play of the Year. Fane was a founding member of Naked Samoans. He played a leading role in Sione's Wedding. Other roles include parts in The Tattooist, bro'Town, Outrageous Fortune and the lead role in Diplomatic Immunity. Fane is part host on the TV2 series Island Wars and morning host for the New Zealand radio station Flava 95.8.
On 23 June 2010, at the inaugural Radio Roast Fane told a celebrity audience that "Hitler had a right", people living with HIV deserved to be "roasted", and "Jews were expendable". Several days after a hoax resignation was circulated to media outlets, Fane apologised to the New Zealand AIDS Foundation (NZAF) and New Zealand Jewish Council. Both organisations accepted his apology on behalf of their communities. Fane was suspended from his Radio Network breakfast show for one week.