Sanguinetti has won two ATP singles titles in 2002, defeating Roger Federer and Andy Roddick in the finals, and one doubles titles (Umag 1997). His career-high singles ranking was World No. 42 (31 December 2005), and he has represented Italy in the Davis Cup since 1998.
In 1998, Sanguinetti made a run to the Wimbledon quarter-finals, losing to Richard Krajicek in straight sets. At the 2005 US Open, Sanguinetti achieved one of the most memorable runs of his career, reaching the fourth round. He defeated Carlos Moyà and Paradorn Srichaphan - the latter in a four and a half hour match - before losing to David Nalbandian. However, he gained a bit of redemption when he upset Nalbandian in the first round of the Rogers Cup in Toronto on 7 August 2006.
So far in 2007, Sanguinetti has got to the quarter-finals in the Chennai Open (knocked out by Rafael Nadal 6–2, 6–3) and in the International Tennis Championships got as far as the quarter-finals (knocked out by Benjamin Becker 7–6, 6–3.) In his other two tournaments he was knocked out in Round One.