The Davson–Danielli model was a model of the plasma membrane of a cell, proposed in 1935 by Hugh Davson and James Danielli. The model describes a phospholipid bilayer that lies between two layers of globular proteins. The phospholipid bilayer had already been proposed by Gorter and Grendel in 1925; however, the flanking proteinaceous layers in the Davson–Danielli model were novel and intended to explain Danielli's observations on the surface tension of lipid bilayers (It is now known that the phospholipid head groups are sufficient to explain the measured surface tension). The Davson–Danielli model predominated until Singer and Nicolson advanced the fluid mosaic model in 1972. The fluid mosaic model expanded on the Davson–Danielli model by including transmembrane proteins, and eliminated the previously-proposed flanking protein layers that were not well-supported by experimental evidence.
- Danielli, J. F.; Davson, H. (1935). "A contribution to the theory of permeability of thin films". Journal of Cellular and Comparative Physiology 5 (4): 495. doi:10.1002/jcp.1030050409.
- Gorter, E.; Grendel, F. (1925). "On Bimolecular Layers of Lipoids on the Chromocytes of the Blood". The Journal of experimental medicine 41 (4): 439–443. doi:10.1084/jem.41.4.439. PMC 2130960. PMID 19868999.
- Wells, W. A. (2005). "The invention of freeze fracture EM and the determination of membrane structure". The Journal of Cell Biology 168 (2): 524. doi:10.1083/jcb1682fta2.
- Singer, S. J.; Nicolson, G. L. (1972). "The fluid mosaic model of the structure of cell membranes". Science 175 (4023): 720–731. doi:10.1126/science.175.4023.720. PMID 4333397.