Dazopride

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Dazopride
Dazopride.png
Systematic (IUPAC) name
4-amino-5-chloro-N-(1,2-diethylpyrazolidin-4-yl)-2-methoxy-benzamide
Clinical data
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 70181-03-2
ATC code None
PubChem CID 54801
ChemSpider 49487
UNII CV07VSP2G8 YesY
Chemical data
Formula C15H23ClN4O2 
Mol. mass 326.82 g/mol

Dazopride (AHR-5531) is an antiemetic and gastroprokinetic agent of the benzamide class which was never marketed.[1][2][3][4][5] It acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist.[3][4][6] In addition to its gastrointestinal effects, dazopride facilitates learning and memory in mice.[7]

See also[edit]

References[edit]

  1. ^ Grant SC, Kris MG, Gralla RJ, Clark RA, Tyson LB (1993). "Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy". Cancer Chemotherapy and Pharmacology 31 (6): 442–4. doi:10.1007/bf00685032. PMID 8453682. 
  2. ^ Alphin RS, Proakis AG, Leonard CA, et al. (May 1986). "Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility". Digestive Diseases and Sciences 31 (5): 524–9. doi:10.1007/bf01320319. PMID 3698769. 
  3. ^ a b Costall B, Domeney AM, Gunning SJ, et al. (July 1987). "The action of dazopride to enhance gastric emptying and block emesis". Neuropharmacology 26 (7A): 669–77. doi:10.1016/0028-3908(87)90227-9. PMID 3114664. 
  4. ^ a b Costall B, Domeney AM, Naylor RJ, Tattersall FD (September 1987). "Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs". Neuropharmacology 26 (9): 1321–6. doi:10.1016/0028-3908(87)90094-3. PMID 2890117. 
  5. ^ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  6. ^ Villalón CM, den Boer MO, Heiligers JP, Saxena PR (January 1991). "Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig". British Journal of Pharmacology 102 (1): 107–12. doi:10.1111/j.1476-5381.1991.tb12140.x. PMC 1917868. PMID 2043916. 
  7. ^ Montgomery, S. A.; Halbreich, Uriel (2000). Pharmacotherapy for mood, anxiety, and cognitive disorders. Washington, DC: American Psychiatric Press. ISBN 0-88048-885-9.