The school originally opened in 1955. In 2005 local voters passed Measure J, a bond measure which included $161 million to completely rebuild the De Anza campus. Reconstruction began in 2009 with a new all-weather track and artificial-turf football field, along with the demolition of the gym and other site preparation work. The new facility was opened for the start of the 2013 - 2014 school year.
The school offers three academies: Health Academy, Information Technology Academy, Law Academy. Students are also offered several clubs including Black Student Union, Anime, Asian-Pacific Islander, Banju Community Club, French, Gay-Straight Alliance, Glee Club, Graffiti Arts, Guitar, Hip-Hop Club, Health Occupational Society of America (HOSA), Interact, MESA, Outdoor Rec, Poetry, Robotics, Shimada, Speech & Debate, Video Game Club and Yearbook.