Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors. A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
^Kischkel, FC; Hellbardt, S, Behrmann, I, Germer, M, Pawlita, M, Krammer, PH, Peter, ME (1995 Nov 15). "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.". The EMBO Journal14 (22): 5579–88. PMC394672. PMID8521815.Check date values in: |date= (help);|accessdate= requires |url= (help)