Debrisoquine

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Debrisoquine[1]
Debrisoquine.svg
Names
IUPAC name
1,2,3,4-tetrahydroisoquinoline-2-carboximidamide
Identifiers
ATC code C02CC04
1131-64-2 YesY
ChEBI CHEBI:34665 YesY
ChEMBL ChEMBL169901 YesY
ChemSpider 2860 YesY
DrugBank DB04840 YesY
Jmol-3D images Image
KEGG C13650 YesY
MeSH Debrisoquine
PubChem 2966
UNII X31CDK040E YesY
Properties
C10H13N3
Molar mass 175.23032
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug metabolizing enzyme.[2]

Synthesis[edit]

Debrisoquin synthesis:[3] W. Wenner, BE 629007 ; idem, U.S. Patent 3,157,573 (1963, 1964 both to Hoffmann-La Roche).

See also[edit]

The guanidine part of the molecule also appears in guanoxan.

References[edit]

  1. ^ Debrisoquine - Compound Summary, PubChem.
  2. ^ Fuhr, U.; Jetter, A.; Kirchheiner, J. (2007). "Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the "Cocktail" Approach". Clinical Pharmacology & Therapeutics 81 (2): 270. doi:10.1038/sj.clpt.6100050.  edit
  3. ^ Wenner, W. (1965). "1,2,3,4-Tetrahydroisoquinoline Derivatives with Antihypertensive Properties". Journal of Medicinal Chemistry 8: 125. doi:10.1021/jm00325a029.  edit