Dectaflur

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Dectaflur
Dectaflur Structural Formula V.1.svg
Systematic (IUPAC) name
9-Octadeceylamine hydrofluoride
Clinical data
Legal status OTC
Routes Topical (gel, solution)
Identifiers
CAS number 36505-83-6
ATC code None
PubChem CID 6433498
ChemSpider 4938643
UNII Q3B1Y93C1S
ChEMBL CHEMBL2106567
Chemical data
Formula C18H38FN 
Mol. mass 287,50 g/mol

Dectaflur (INN) is a fluoride-containing substance used for the prevention and treatment of dental caries, sensitive teeth, and the refluoridation of damaged tooth enamel, typically in combination with olaflur.[1]

Chemistry and mechanism of action[edit]

Dectaflur consists of oleyl amine (the amine corresponding to oleyl alcohol) and hydrofluoric acid. Oleyl amine with its long lipophilic hydrocarbon chain has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the top layers of the enamel, reaching a depth of only a few nanometers. The precise mechanism of action is unknown.[2]

Side effects[edit]

Like other fluorides, dectaflur is toxic when overdosed over an extended period of time. Especially in children, before the development of the permanent teeth, overdosage can lead to dental fluorosis.[3]

References[edit]

  1. ^ Haberfeld, H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 3-85200-196-X. 
  2. ^ Müller, F.; Zeitz, C.; Mantz, H.; Ehses, K. H.; Soldera, F.; Schmauch, J.; Hannig, M.; Hüfner, S.; Jacobs, K. (2010). "Elemental Depth Profiling of Fluoridated Hydroxyapatite: Saving Your Dentition by the Skin of Your Teeth?". Langmuir 26 (24): 18750–18759. doi:10.1021/la102325e. PMID 21090577.  edit
  3. ^ Alvarez, J. A.; Rezende, K. M.; Marocho, S. M.; Alves, F. B.; Celiberti, P.; Ciamponi, A. L. (2009). "Dental fluorosis: Exposure, prevention and management". Medicina oral, patologia oral y cirugia bucal 14 (2): E103–E107. PMID 19179949.  edit