Deep cerebellar nuclei

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Deep cerebellar nuclei
Gray707.png
Sagittal section through right cerebellar hemisphere. The right olive has also been cut sagitally. (Nucleus dentatus labeled at center top.)
CerebCircuit.png
Microcircuitry of the cerebellum. Excitatory synapses are denoted by (+) and inhibitory synapses by (-).
MF: Mossy fiber.
DCN: Deep cerebellar nuclei.
IO: Inferior olive.
CF: Climbing fiber.
GC: Granule cell.
PF: Parallel fiber.
PC: Purkinje cell.
GgC: Golgi cell.
SC: Stellate cell.
BC: Basket cell.
Details
Latin nuclei cerebelli
Part of Cerebellum
Components Dentate nucleus, Emboliform nucleus, Fastigial nucleus, Globose nucleus
Superior cerebellar
Identifiers
Gray's p.796
NeuroNames hier-679
NeuroLex ID Deep cerebellar nuclear complex
Dorlands
/Elsevier
n_11/12580684
Anatomical terms of neuroanatomy

The cerebellum has four deep cerebellar nuclei embedded in the white matter in its center.

Inputs[edit]

These nuclei receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber and climbing fiber pathways. Most output fibers of the cerebellum originate from these nuclei. One exception is that fibers from the flocculonodular lobe synapse directly on vestibular nuclei without first passing through the deep cerebellar nuclei. The vestibular nuclei in the brainstem are analogous structures to the deep nuclei, since they receive both mossy fiber and Purkinje cell inputs.[citation needed]

Specific nuclei[edit]

From lateral to medial, the four deep cerebellar nuclei are the dentate, emboliform, globose, and fastigii. An easy mnemonic device to remember their names and positions relative to the midline is the phrase "Fat Guys Eat Donuts," where each letter indicates the medial to lateral location in the cerebellar white matter.

Some animals, including humans, do not have distinct emboliform and globose nuclei, instead having a single, fused nucleus interpositus (interposed nucleus). In animals with distinct emboliform and globose nuclei, the term interposed nuclei is often used to refer collectively to these two nuclei.

Topography[edit]

In general, each pair of deep nuclei is associated with a corresponding region of cerebellar surface anatomy.

  • The dentate nuclei are deep within the lateral hemispheres,
  • the interposed nuclei are located in the paravermal (intermediate) zone,
  • and the fastigial nuclei are in the vermis.

These structural relationships are generally maintained in the neuronal connections between the nuclei and associated cerebellar cortex,

  • with the dentate nucleus receiving most of its connections from the lateral hemispheres,
  • the interposed nuclei receiving inputs mostly from the paravermis,
  • and the fastigial nucleus receiving primarily afferents from the vermis.

External links[edit]