|This article needs additional citations for verification. (April 2011)|
Established in 1999 by former AM:PM and Cooltempo A&R man Simon Dunmore and initially co-owned by London nightclub and label Ministry of Sound, Defected's first release was Soulsearcher's "I Can't Get Enough", which reached No. 5 in the UK singles chart. This early success was followed up with Roger Sanchez's "Another Chance", which hit No. 1 in the UK singles chart in 2001. To date, Defected has released more than 300 singles from artists such as Bob Sinclar, Kings of Tomorrow, MURK, Inner City, Dennis Ferrer, Marc Kinchen (MK), Copyright and Yousef.
In addition to the 2001 No.1 one from Sanchez, Defected has released a number of records that have had a significant impact on the house scene. Kings of Tomorrow's "Finally" was voted the 31st best track of 2000–2010 by leading electronic dance music portal Resident Advisor, and is still a regular feature of DJ sets to this day. Bob Sinclar's 2005 track "Love Generation" reached No.12 in the UK singles chart and was a massive hit all over Europe and in Australia, achieving one of the longest runs of all time in the German singles charts and going on to sell over 1 million copies worldwide.The Irish Duo Fish go deep also had success with their hit "Cure and the Cause" which stayed in the Beatport top 100 for almost a year.
More recently, Defected have found success with underground hits like Dennis Ferrer's "Hey Hey". In addition, they have released a number of underground hits from both seminal recordings artists and up and coming DJs and producers, including Inner City 'Future', Intruder feat. Jai 'Amame', Flashmob 'Need In Me', Pirupa 'Party Non Stop' Candi Staton 'Hallelujah Anyway', Noir & Haze 'Around', FCL 'It’s You', Kings of Tomorrow feat. April 'Fall For You', Rachel Row 'Follow The Step' and Storm Queen 'Look Right Through', many of which have won awards or gone on to be some of the biggest club records of the year.
Defected's acclaimed In The House series launched in 2003 with Jay-J & Miguel Migs and has since featured artists such as Loco Dice, Gilles Peterson, The Shapeshifters, Louie Vega and Tensnake, as well as annual compilations dedicated to Ibiza and Miami and other notable clubbing destinations.
As Defected Records approached its 15 year anniversary, the new 2013 brand identity marks a significant turning point for the label. Conceptualised by renowned  designer, DJ and producer Trevor Jackson working alongside Defected founder Simon Dunmore as well as other members of the Defected team, the new brand identity stripped the appearance down to its bare essentials and marked a clearly defined new look for the label.
Also in 2013, Defected launched their breakout label DFTD. DFTD has a more diverse musical remit than the main Defected label, and releases a broad range of electronic music, focusing on quality, discerning dance music. The first release 'Hope EP' by Guti, was received very favourably.
Defected In The House events bring some of the world's biggest DJs to clubbers around the globe, with regular events at London's Ministry of Sound, Singapore's Zouk and Jakarta's Dragon Fly. Defected In The House also held a residency at Pacha in Ibiza throughout the summer season (June – September) for 8 years. In 2013, Defected left Pacha  and took up residency at the Cipriani-owned Booom!, at which it has been the most successful night over the summer season.