Defensin, beta 1

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Defensin, beta 1
Protein DEFB1 PDB 1e4s.png
PDB rendering based on 1e4s.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DEFB1 ; BD1; DEFB-1; DEFB101; HBD1
External IDs OMIM602056 HomoloGene88476 GeneCards: DEFB1 Gene
RNA expression pattern
PBB GE DEFB1 210397 at tn.png
More reference expression data
Species Human Mouse
Entrez 1672 n/a
Ensembl ENSG00000164825 n/a
UniProt P60022 n/a
RefSeq (mRNA) NM_005218 n/a
RefSeq (protein) NP_005209 n/a
Location (UCSC) Chr 8:
6.73 – 6.74 Mb
PubMed search [1] n/a

Beta-defensin 1 is a protein that in humans is encoded by the DEFB1 gene.[1][2]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member defensin, alpha 1, and has been implicated in the pathogenesis of cystic fibrosis.[2]


  1. ^ Bensch KW, Raida M, Magert HJ, Schulz-Knappe P, Forssmann WG (Sep 1995). "hBD-1: a novel beta-defensin from human plasma". FEBS Lett 368 (2): 331–5. doi:10.1016/0014-5793(95)00687-5. PMID 7628632. 
  2. ^ a b "Entrez Gene: DEFB1 defensin, beta 1". 

Further reading[edit]