Deflazacort

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Deflazacort
Deflazacort structure.svg
Systematic (IUPAC) name
(11β,16β)-21-(acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Routes Oral
Pharmacokinetic data
Protein binding 40%
Metabolism By plasma esterases, to active metabolite
Half-life 1.1–1.9 hours (metabolite)
Excretion Renal (70%) and fecal (30%)
Identifiers
CAS number 14484-47-0 YesY
ATC code H02AB13
PubChem CID 26709
ChemSpider 164861 N
UNII KR5YZ6AE4B YesY
KEGG D03671 YesY
Chemical data
Formula C25H31NO6 
Mol. mass 441.517 g/mol
 N (what is this?)  (verify)

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.

Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort.[1] Its potency is around 70–90% that of prednisone.[2]

It is sold in the United Kingdom by Shire under the trade name Calcort;[2] in Brazil as Cortax, Decortil, and Deflanil; in India as MOAID, Defolet(Schwartz), DFZ, Decotaz, and DefZot; in Panama as Zamen, Spain as Zamene and in Honduras as Flezacor.[3] It is not available in the United States.

References[edit]

  1. ^ Möllmann, H; Hochhaus, G; Rohatagi, S; Barth, J; Derendorf, H (1995). "Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone". Pharmaceutical research 12 (7): 1096–100. PMID 7494809. 
  2. ^ a b "Calcort". electronic Medicines Compendium. June 11, 2008.  Retrieved on October 28, 2008.
  3. ^ (Portuguese) "Substâncias: DEFLAZACORT". Centralx. 2008.  Retrieved on October 28, 2008.