Delta-like 1

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Delta-like 1 (Drosophila)
Symbols DLL1 ; DELTA1; DL1; Delta
External IDs OMIM606582 MGI104659 HomoloGene4104 GeneCards: DLL1 Gene
RNA expression pattern
PBB GE DLL1 gnf1h00074 at tn.png
More reference expression data
Species Human Mouse
Entrez 28514 13388
Ensembl ENSG00000198719 ENSMUSG00000014773
UniProt O00548 Q61483
RefSeq (mRNA) NM_005618 NM_007865
RefSeq (protein) NP_005609 NP_031891
Location (UCSC) Chr 6:
170.59 – 170.6 Mb
Chr 17:
15.37 – 15.38 Mb
PubMed search [1] [2]

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[1]

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[1]


Delta-like 1 has been shown to interact with NOTCH2.[2][3][4]


  1. ^ a b "Entrez Gene: DLL1 delta-like 1 (Drosophila)". 
  2. ^ Shimizu, K; Chiba S; Saito T; Kumano K; Takahashi T; Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. (United States) 276 (28): 25753–8. doi:10.1074/jbc.M103473200. ISSN 0021-9258. PMID 11346656. 
  3. ^ Blaumueller, C M; Qi H; Zagouras P; Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell (UNITED STATES) 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. ISSN 0092-8674. PMID 9244302. 
  4. ^ Shimizu, K; Chiba S; Hosoya N; Kumano K; Saito T; Kurokawa M; Kanda Y; Hamada Y; Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. ISSN 0270-7306. PMC 88767. PMID 10958687. 

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