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IUPAC names
(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-4-(methylsulfanyl)butanamido]-3-phenylpropanamido]-3-(1H-imidazol-4-yl)propanamido]-4-methylpentanamido]-4-(methylsulfanyl)butanamido]-3-carbamoylpropanoic acid
Other names
Deltorphin A; Dermenkephalin
ChemSpider 2299380
Jmol-3D images Image
PubChem 3035060
Molar mass 955.154 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Deltorphin, also known as deltorphin A and dermenkephalin, is a naturally occurring, exogenous opioid heptapeptide and thus, exorphin, with the amino acid sequence Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2.[1][2][3] Along with the other deltorphins (such as deltorphin I and deltorphin II) and the dermorphins, deltorphin is endogenous to frogs of the genus Phyllomedusa such as P. bicolor and P. sauvagei where it is produced in their skin, and is not known to occur naturally in any other species.[1][2][4] Deltorphin is one of the highest affinity and most selective naturally occurring opioid peptides known, acting as a very potent and highly specific agonist of the δ-opioid receptor.[1][2][3]

See also[edit]


  1. ^ a b c Kreil G, Barra D, Simmaco M, et al. (March 1989). "Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for delta opioid receptors". European Journal of Pharmacology 162 (1): 123–8. doi:10.1016/0014-2999(89)90611-0. PMID 2542051. 
  2. ^ a b c Mor A, Delfour A, Sagan S, et al. (September 1989). "Isolation of dermenkephalin from amphibian skin, a high-affinity delta-selective opioid heptapeptide containing a D-amino acid residue". FEBS Letters 255 (2): 269–74. doi:10.1016/0014-5793(89)81104-4. PMID 2551734. 
  3. ^ a b Erspamer V, Melchiorri P, Falconieri-Erspamer G, et al. (July 1989). "Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites". Proceedings of the National Academy of Sciences of the United States of America 86 (13): 5188–92. doi:10.1073/pnas.86.13.5188. PMC 297583. PMID 2544892. 
  4. ^ Temussi PA, Picone D, Tancredi T, et al. (April 1989). "Conformational properties of deltorphin: new features of the delta-opioid receptor". FEBS Letters 247 (2): 283–8. doi:10.1016/0014-5793(89)81353-5. PMID 2541018.