Denio Junction is about two miles (3 km) south of Denio, at the junction of State Route 140 and State Route 292. Denio Junction's motel provides gasoline (although not reliably), food, groceries, and lodging. Air transportation is available at the Denio Junction Airport. This is a two-runway graded airstrip. There is no scheduled air or ground transportation serving this field, which is a short walk from any part of Denio Junction.
Denio was named for Aaron Denio, who settled in the area in 1885. Aaron Denio was born in 1824 in Illinois and traveled to California in 1860. He worked in milling, mining, and farming in Nevada and California for 25 years before settling near the Oregon-Nevada border. He died at Denio in 1907. Denio post office was established in Oregon in 1888. After World War II a number of businesses relocated south of the state line to take advantage of Nevada's more liberal liquor and gambling laws. The post office moved and reopened in Nevada in 1950.