Dense granule

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Dense granule
Details
Latin granulum delta
Identifiers
Code TH H2.00.04.1.03006
Anatomical terminology

Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles.

In unicellular organisms[edit]

They are found in animals and in unicellular organisms including Apicomplexa protozoans.

They are also found in Entamoeba.[1]

In multicellular organisms[edit]

Components[edit]

The dense granules of human platelets contain adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium (which is necessary for several steps of the coagulation cascade), histamine and serotonin.[2]

Clinical significance[edit]

A deficiency of CD63 can be associated with Hermansky-Pudlak syndrome.[3]

See also[edit]

References[edit]

  1. ^ James Joseph Marr; Timothy W. Nilsen; Richard Komuniecki (2003). Molecular medical parasitology. Academic Press. pp. 254–. ISBN 978-0-12-473346-6. Retrieved 12 November 2010. 
  2. ^ Stuart H. Orkin; David G. Nathan; David Ginsburg; A. Thomas Look (2009). Nathan and Oski's hematology of infancy and childhood. Elsevier Health Sciences. pp. 1386–. ISBN 978-1-4160-3430-8. Retrieved 2 November 2010. 
  3. ^ Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard J (1993). "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.". J Clin Invest 91 (4): 1775–82. doi:10.1172/JCI116388. PMC 288158. PMID 7682577.