Dense granule
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| Dense granule | |
|---|---|
| Latin | granulum delta |
| Code | TH H2.00.04.1.03006 |
Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles.
Contents |
[edit] In unicellular organisms
They are found in animals and in unicellular organisms including Apicomplexa protozoans.
They are also found in Entamoeba.[1]
[edit] In multicellular organisms
[edit] Components
The dense granules of human platelets contain adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium which is necessary for several steps of the coagulation cascade, and serotonin.[2]
[edit] Clinical significance
A deficiency of CD63 can be associated with Hermansky-Pudlak syndrome.[3]
[edit] See also
[edit] References
- ^ James Joseph Marr; Timothy W. Nilsen; Richard Komuniecki (2003). Molecular medical parasitology. Academic Press. pp. 254–. ISBN 9780124733466. http://books.google.com/books?id=KjSCOT_cUXQC&pg=PA254. Retrieved 12 November 2010.
- ^ Stuart H. Orkin; David G. Nathan; David Ginsburg; A. Thomas Look (2009). Nathan and Oski's hematology of infancy and childhood. Elsevier Health Sciences. pp. 1386–. ISBN 9781416034308. http://books.google.com/books?id=_9CmOIvgJm4C&pg=PA1386. Retrieved 2 November 2010.
- ^ Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard J (1993). "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.". J Clin Invest 91 (4): 1775–82. doi:10.1172/JCI116388. PMC 288158. PMID 7682577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=288158.
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