Deoxyribonuclease II

From Wikipedia, the free encyclopedia
Jump to: navigation, search
deoxyribonuclease II alpha
Identifiers
Symbol DNASE2
Alt. symbols DNASE2A, DRN2, DNL, DNL2
Entrez 1777
HUGO 2960
OMIM 126350
RefSeq NM_001375
UniProt O00115
Other data
Locus Chr. 19 p13.2
deoxyribonuclease II beta
Identifiers
Symbol DNASE2B
Entrez 58511
HUGO 28875
OMIM 608057
RefSeq NM_021233
UniProt Q8WZ79
Other data
Locus Chr. 1 p22.3

Deoxyribonuclease II (EC 3.1.22.1, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease, acid DNase) hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3'-phosphates. As the name implies, it is more effective at acid pH.

There are several known DNases II, including:

  • DNase II alpha (usually just called DNase II)
  • DNase II beta (also called DLAD, or DNase II-Like Acid DNase)

External links[edit]