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Depletion may refer to:
- Depletion (accounting), an accounting concept
- Depletion region, a concept of semiconductor physics
- Depletion width, a concept of semiconductor physics
- Grain boundary depletion, a mechanism of corrosion
- Oil depletion, the declining of oil supply
- Overdrafting, extracting groundwater beyond the equilibrium yield of an aquifer
- Ozone depletion, a decline in the total amount of ozone in Earth's stratosphere
- Resource depletion, the exhaustion of raw materials within a region
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