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Dequalinium chloride
Dequalinium chloride.png
IUPAC name
1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) decyl]-2-methyl-4-quinolin-1-iumamine dichloride
ATC code D08AH01
G01AC05, R02AA02
ChEMBL121663 YesY
ChemSpider 2886 YesY
DrugBank DB04209 YesY
Jmol-3D images Image
MeSH Dequalinium
PubChem 10649
Molar mass 527.57 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications:

Dequadin an antiseptic and disinfectant. It is a topical bacteriostat. It is used in wound dressings and mouth infections and may also have antifungal action. It may cause skin ulceration.

Fluomizin, vaginal tablets containing 10 mg dequalinium chloride, are used for treating vaginal bacterial conditions (i.e. Bacterial Vaginosis).

The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by a dodecylene chain.


Dequalinium salts may be used to treat malaria.[1] As dequalinium chloride, it can be used in lozenges to cure sore throats however while this is effective in vitro, it is not effective in cases of streptococci infections [2]


  1. ^ "US Patent 4946849". United States Patents and Trademarks Office (USPTO). 10 October 1989. Retrieved 2008-03-15. 
  2. ^ Krämer W. (1977). "[Treatment of tonsilitis with dequalinium chloride]". Fortschr Med. (in German) 95 (16): 1108–10. PMID 856702. 

Further reading[edit]

  • Gamboa-Vujicic, Gisela; Emma, Dennis A.; Liao, Shu Y.; Fuchtner, Carlos; Manetta, Alberto (1993). "Toxicity of the mitochondrial poison dequalinium chloride in a murine model system". Journal of Pharmaceutical Sciences 82 (3): 231–5. doi:10.1002/jps.2600820302. PMID 8450414. 

External links[edit]