Dermatographic urticaria
From Wikipedia, the free encyclopedia
| Dermatographic urticaria | |
| Classification and external resources | |
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|---|---|
| Dermatographic urticaria is sometimes called "skin writing". | |
| ICD-10 | L50.3 |
| ICD-9 | 708.3 |
| OMIM | 125635 |
| DiseasesDB | 12736 |
| eMedicine | derm/446 |
Dermatographic urticaria (also known as dermographism, dermatographism or "skin writing") is a skin disorder seen in 4–5% of the population and is one of the most common types of urticaria,[1] in which the skin becomes raised and inflamed when stroked or rubbed with a dull object.[2]
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[edit] Presentation
The symptoms are thought to be caused by mast cells in the surface of the skin releasing histamines without the presence of antigens, due to the presence of a weak membrane surrounding the mast cells. The histamines released cause the skin to swell in the affected areas.
This weak membrane easily and rapidly breaks down under physical pressure causing an allergic-like reaction, generally a red wheal (welt) to appear on the skin. It can often be confused with an allergic reaction to the object causing a scratch, when in fact it is the act of being scratched that causes a wheal to appear. These wheals are a subset of urticaria (hives) that appear within minutes, accompanied by a sensation of burning, and itchiness. The first outbreak of urticaria can lead to others on body parts not directly stimulated, scraped or scratched. In a normal case the swelling will reduce itself with no treatment within 15–30 minutes, but in extreme cases, itchy red wheals may last anywhere from a few hours to days.
It has been reported that one artist with dermatographism uses her skin as her medium.[3]
[edit] Causes
The underlying cause of dermographism is not known, and can last for many years without relief. 95% of chronic cases are never solved. Sometimes the condition goes away, sometimes it stays forever. It is not a life threatening disease and is not contagious (transferable to other persons).
Symptoms can be induced by stress, tight or abrasive clothing, watches, glasses, energetic kissing, heat, cold,[4] or anything that causes stress to the skin or the patient. In many cases it is merely a minor annoyance, but in some rare cases symptoms are severe enough to impact a patient's life.
[edit] Treatment
Dermographism can be treated by antihistamines which prevents the histamine from causing the reaction, and these may need to be given as a combination of H1 antagonists, or possibly with an H2-receptor antagonist such as cimetidine.[5][6]
Not taking hot baths or showers may help if it is generalized (all over) and possibly for localized (in a specific area) If not taking showers helps, it may be a condition called shower eczema. If it mainly affects the head it may be psoriasis. In rare cases, allergy tests may uncover substances the patient is allergic to. Using biodegradable or hypo-allergenic soaps and laundry supplies may help.
While cromoglycate, which prevents histamine from being released from mast cells, is used topically in rhinitis and asthma, it is not effective orally for treating chronic urticaria.[7][8]
[edit] References
- ^ Jedele KB, Michels VV (1991). "Familial dermographism". Am. J. Med. Genet. 39 (2): 201–3. doi:. PMID 2063925. http://www3.interscience.wiley.com/cgi-bin/fulltext/110516063/PDFSTART.
- ^ Kontou-Fili K, Borici-Mazi R, Kapp A, Matjevic LJ, Mitchel FB (1997). "Physical urticaria: classification and diagnostic guidelines. An EAACI position paper". Allergy 52 (5): 504–13. doi:. PMID 9201361.
- ^ Hunte, Tracie (March 14, 2008). "Artist: 'I Use My Skin as a Canvas'". ABC News. http://abcnews.go.com/Health/story?id=4446929. Retrieved on 2008-10-05.
- ^ Kaplan AP (1984). "Unusual cold-induced disorders: cold-dependent dermatographism and systemic cold urticaria". J Allergy Clin Immunol 73 (4): 453–6. doi:. PMID 6200525.
- ^ Wozel G, Sahre EM, Barth J (1990). "[Effectiveness of combination treatment with H1-(Tavegyl) and H2-antagonists (Altramet) in chronic/chronically-recurrent urticaria]" (in German). Dermatologische Monatschrift 176 (11): 653–9. PMID 2083605.
- ^ Negro-Alvarez JM, Miralles-López JC (2001). "Chronic idiopathic urticaria treatment" ([dead link] – Scholar search). Allergologia et immunopathologia 29 (4): 129–32. PMID 11674926. http://db.doyma.es/cgi-bin/wdbcgi.exe/doyma/mrevista.pubmed_full?inctrl=05ZI0102&rev=105&vol=29&num=4&pag=129.
- ^ Thormann J, Laurberg G, Zachariae H (March 1980). "Oral sodium cromoglycate in chronic urticaria". Allergy 35 (2): 139–41. doi:. PMID 6770707.
- ^ Soter NA (December 1990). "Urticaria: current therapy". The Journal of allergy and clinical immunology 86 (6 Pt 2): 1009–14. doi:. PMID 1979795.
