A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug while at the same time, avoid being classified as illegal and/or avoid detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with less side effects and were later co-opted for illicit use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances has not been thoroughly evaluated in animal and human trials, the use of these drugs may result in unexpected side effects.
The development of designer drugs may be considered a subfield of drug design. The exploration of modifications to known active drugs — such as their structural analogues, stereoisomers, and derivatives — yields drugs that may differ significantly in effects from their “parent” drug (e.g., showing increased potency, or decreased side effects). In some instances, designer drugs have similar effects to other known drugs, but have completely dissimilar chemical structures. Despite being a very broad term, applicable to almost every synthetic drug, it is often used to connotate synthetic recreational drugs, sometimes even those which have not been designed at all. This article specifically discusses recreational drugs. For the discussion of drug design in pharmacology, please see drug design.
In some jurisdictions, drugs that are highly similar in structure to a prohibited drug are illegal to trade regardless of that drug's legal status. In other jurisdictions, their trade is a legal grey area, making them grey market goods. Some jurisdictions may have analogue laws which ban drugs similar in chemical structure to other prohibited drugs, while some designer drugs may be prohibited irrespective of the legal status of structurally similar drugs; in both cases, their trade may take place on the black market.
- 1 History
- 2 Safety
- 3 Law
- 4 List
- 4.1 Opioids
- 4.2 Psychedelics
- 4.3 Dissociatives
- 4.4 Piperazines
- 4.5 Empathogens
- 4.6 Stimulants
- 4.7 Sedatives
- 4.8 Cannabinoids
- 4.9 Anabolic steroids
- 4.10 SARMs
- 4.11 Peptides
- 4.12 PDE5 inhibitors
- 5 See also
- 6 References
- 7 External links
||The examples and perspective in this article or section might have an extensive bias or disproportional coverage towards one or more specific regions. (May 2010)|
Following the passage of the second International Opium Convention in 1925, which specifically banned morphine, the diacetyl ester of morphine, heroin, and a number of alternative esters of morphine quickly started to be manufactured and sold. The most notable of these were dibenzoylmorphine and acetylpropionylmorphine, which have virtually identical effects to heroin but were not covered by the Opium Convention. This then led the Health Committee of the League of Nations to pass several resolutions attempting to bring these new drugs under control, ultimately leading in 1930 to the first broad analogues provisions extending legal control to all esters of morphine, oxycodone, and hydromorphone. Another early example of what could loosely be termed designer drug use, was during the Prohibition era in the 1930s, when diethyl ether was sold and used as an alternative to illegal alcoholic beverages in a number of countries.
During the 1960s and 1970s, a number of new synthetic hallucinogens were introduced, with a notable example being the sale of highly potent tablets of DOM in San Francisco in 1967. There was little scope to prosecute people over drug analogues at this time, with new compounds instead being added to the controlled drug schedules one by one as they became a problem, but one significant court case from this period was in 1973, when Tim Scully and Nicholas Sand were prosecuted for making the acetyl amide of LSD, known as ALD-52. At this time ALD-52 was not a controlled drug, but they were convicted on the grounds that in order to make ALD-52, they would have had to be in possession of LSD, which was illegal. The late 1970s also saw the introduction of various analogues of phencyclidine (PCP) to the illicit market.
The modern use of the term designer drug was coined in the 1980s to refer to various synthetic opioid drugs, based mostly on the fentanyl molecule (such as α-methylfentanyl). The term gained widespread popularity when MDMA (ecstasy) experienced a popularity boom in the mid-1980s. When the term was coined in the 1980s, a wide range of narcotics were being sold as heroin on the black market. Many were based on fentanyl or meperidine. One, MPPP, was found in some cases to contain an impurity called MPTP, which caused brain damage that could result in a syndrome identical to full-blown Parkinson's disease, from only a single dose. Other problems were highly potent fentanyl analogues, which were sold as China White, that caused many accidental overdoses.
Because the government was powerless to prosecute people for these drugs until after they had been marketed successfully, laws were passed to give the DEA power to emergency schedule chemicals for a year, with an optional 6-month extension, while gathering evidence to justify permanent scheduling, as well as the analogue laws mentioned previously. Emergency-scheduling power was used for the first time for MDMA. In this case, the DEA scheduled MDMA as a Schedule I drug and retained this classification after review, even though their own judge ruled that MDMA should be classified Schedule III on the basis of its demonstrated uses in medicine. The emergency scheduling power has subsequently been used for a variety of other drugs including 2C-B, AMT, and BZP. In 2004, a piperazine drug, TFMPP, became the first drug that had been emergency-scheduled to be denied permanent scheduling and revert to legal status.
The late 1980s and early 1990s also saw the re-emergence of methamphetamine in the United States as a widespread public health issue, leading to increasing controls on precursor chemicals in an attempt to cut down on domestic manufacture of the drug. This led to several alternative stimulant drugs emerging, the most notable ones being methcathinone and 4-methylaminorex, but, despite attracting enough attention from authorities to provoke legal scheduling of these compounds, their distribution was relatively limited in extent and methamphetamine continued to dominate the illicit synthetic stimulant market overall.
In the late 1990s and early 2000s, there was a huge explosion in designer drugs being sold over the internet. The term and concept of "research chemicals" was coined by some marketers of designer drugs (in particular, of psychedelic drugs in the tryptamine and phenethylamine family). The idea was that, by selling the chemicals as for "scientific research" rather than human consumption, the intent clause of the U.S. analogue drug laws would be avoided. Nonetheless, the DEA raided multiple suppliers, first JLF Primary Materials, and then multiple vendors (such as RAC Research) several years later in Operation Web Tryp. This process was accelerated greatly when vendors began advertising via search engines like Google by linking their sites to searches on key words such as chemical names and terms like psychedelic or hallucinogen. Widespread discussion of consumptive use and the sources for the chemicals in public forums also drew the attention of the media and authorities.
In 2004, the US Drug Enforcement Administration raided and shut down several Internet-based research chemical vendors in an operation called Web Tryp. With help from the authorities in India and China, two chemical manufacturers were also closed. Many other internet-based vendors promptly stopped doing business, even though their products were still legal throughout much of the world.
Most substances that were sold as "research chemicals" in this period of time are hallucinogens and bear a chemical resemblance to drugs such as psilocybin and mescaline. As with other hallucinogens, these substances are often taken for the purposes of facilitating spiritual processes, mental reflection or recreation. Some research chemicals on the market were not psychoactive, but can be used as precursors in the synthesis of other potentially psychoactive substances, for example, 2C-H, which could be used to make 2C-B and 2C-I among others. Extensive surveys of structural variations have been conducted by pharmaceutical corporations, universities and independent researchers over the last century, from which some of the presently available research chemicals derive. One particularly notable researcher is Dr. Alexander Shulgin, who presented syntheses and pharmacological explorations of hundreds of substances in the books TiHKAL and PiHKAL (co-authored with Ann Shulgin), and has served as an expert witness for the defense in several court cases against manufacturers of psychoactive drugs.
The majority of chemical suppliers sold research chemicals in bulk form as powder, not as pills, as selling in pill form would invalidate the claims that they were being sold for non-consumptive research. Active dosages vary widely from substance to substance, ranging from micrograms to hundreds of milligrams, but while it is critical for the end user to weigh doses with a precision scale, instead of guessing ("eyeballing"), many users did not do this and this led to many emergency room visits and several deaths, which were a prominent factor leading to the emergency scheduling of several substances and eventually Operation Web Tryp. Some compounds such as 2C-B and 5-Meo-DiPT did eventually increase in popularity to the point that they were sold in pill form to reach a wider market, and acquired popular street names ("Nexus" and "Foxy," respectively). Once a chemical reaches this kind of popularity, it is usually just a matter of time before it is added to the list of scheduled (i.e., illegal) drugs.
The late 1990s and early 2000s also saw the first widespread use of novel anabolic steroids by athletes in competition. Steroids had been banned by the International Olympic Committee since 1976, but due to the large number of different anabolic agents available for human and veterinary use, the ability of laboratories to test for all available drugs had always lagged behind the ability of athletes to find new compounds to use. The introduction of increasingly formalised testing procedures, especially with the creation of the World Anti-Doping Agency in 1999, made it much more difficult for athletes to get away with using these drugs without detection, which then led to the synthesis of novel and potent anabolic steroid drugs such as tetrahydrogestrinone (THG), which were not detectable by the standard tests.
While through recent history most designer drugs had been either opioids, hallucinogens, or anabolic steroids, the range of possible compounds is limited only by the scientific and patent literature, and recent years have been characterised by a broadening of the range of compounds sold as designer drugs. These have included a wide variety of designer stimulants such as geranamine, mephedrone, MDPV and desoxypipradrol, several designer sedatives such as methylmethaqualone and premazepam, and designer analogues of sildenafil (Viagra), which have been reported as active compounds in "herbal" aphrodisiac products. Designer cannabinoids are another recent development, with two compounds JWH-018 and (C8)-CP 47,497 initially found in December 2008 as active components of "herbal smoking blends" sold as legal alternatives to marijuana, and subsequently a growing range of synthetic cannabinoid agonists have continued to appear, including by 2010 novel compounds such as RCS-4, RCS-8, and AB-001, which had never been reported in the literature, and appear to have been invented by designer drug manufacturers themselves. Another novel development is the use of research ligands for cosmetic rather than strictly recreational purposes, such as grey-market internet sales of the non-approved alpha-melanocyte-stimulating hormone tanning drugs known as melanotan peptides.
“...what is new is the wide range of substances now being explored, the aggressive marketing of products that have been intentionally mislabelled, the growing use of the internet, and the speed at which the market reacts to control measures.”
Mephedrone and the cathinones marked somewhat of a turning point for designer drugs, turning them from little known, ineffective substances sold in head shops to powerful substances able to compete with classical drugs on the black market. Mephedrone especially experienced a somewhat meteoric rise in popularity in 2009 and the resulting media panic resulted in its prohibition in multiple countries, including, unusually, China. Following this there was a considerable emergence of other cathinones which attempted to mimic the effects of mephedrone, and with a newly attracted customer base, plenty of money to drive innovation.
Subsequently the market rapidly expanded, with more and more substances being detected every year. In 2009, the EMCDDA's early warning system discovered 24 new drugs. In 2010, it found another 41; in 2011, another 49; and in 2012, there were 73 more. In 2013, a further 81 were identified: a total of 268 new drugs in just four years. These have not been limited to cathinones, with 35% being cannabinoids and the rest being composed of stimulants, psychedelics, dissociatives and to a lesser extent, every other class of drugs, even ibogoids and nootropics.
The safety of research chemicals is untested and little if any research has been done on the toxicology or pharmacology of most of these drugs. Few, if any, human or animal studies have been done. Many research compounds have produced unexpected side-effects and adverse incidents due to the lack of screening for off-target effects prior to marketing; both bromo-dragonfly and mephedrone seem to be capable of producing pronounced vasoconstriction under some circumstances, which has resulted in several deaths, although the mechanism remains unclear. Substituted phenethylamines such as the 2C family and substituted amphetamines such as the DOx family have also caused a limited number of deaths.
Due to the recent development of many designer drugs, laws banning or regulating their use have not been developed yet, and in recent cases novel drugs have appeared directly in response to legislative action, to replace a similar compound that had recently been banned. Many of the chemicals fall under the various drug analogue legislations in certain countries, but most countries have no general analogue act or equivalent legislation and so novel compounds may fall outside of the law after only minor structural modifications.
In the United States, the Controlled Substances Act was amended by the Controlled Substance Analogue Enforcement of 1986, which attempted to ban designer drugs pre-emptively by making it illegal to manufacture, sell, or possess chemicals that were substantially similar in chemistry and pharmacology to Schedule I or Schedule II drugs.
Other countries have dealt with the issue differently. In some, the new drugs are banned as they become a concern, as in Germany, Canada, the United Kingdom, and Sweden. In Sweden, the police and customs from April 2011 may also seize drugs that are not on the list of drugs covered by the anti-drug laws if the police suspect that the purpose of the holding is related to drug abuse. Following a decision by a prosecutor, the police may destroy the seized drugs.
Some countries, such as Australia, have gone the opposite direction and enacted sweeping bans based on chemical structure only, making chemicals illegal even before they are created — if a theoretical chemical fits a set of rules regarding substitutions and alterations of an already-banned drug, it too is banned. The controlled substance analogue law under both Australian Federal law and that of some individual states such as New South Wales is so broad that it would cover millions of compounds that have never been made, simply on the basis that they bear a vague resemblance to one of the drugs on the illegal list. However, it would still not cover drugs that have no structural similarity to any controlled drug, even if they produced similar effects.
|This section requires expansion. (June 2008)|
Temporary class drug
A temporary class drug is a relatively new status for controlled drugs, which has been adopted in some jurisdictions, notably New Zealand and the United Kingdom, to attempt to bring newly synthesised designer drugs under legal control. The controlled drug legislation in these jurisdictions requires drug scheduling decisions to follow an evidence-based process, where the harms of the drug are assessed and reviewed so that an appropriate legal status can be assigned. Since many designer drugs sold in recent years have had little or no published research that could help inform such a decision, they have been widely sold as "legal highs", often for months, before sufficient evidence accumulates to justify placing them on the controlled drug schedules.
In the UK to avoid being controlled by the Medicines Act, designer drugs such as mephedrone have been described as "bath salts" or "plant food", despite the compounds having no history of being used for these purposes.
In the USA, similar descriptions have been used to describe mephedrone as well as methylone and methylenedioxypyrovalerone (MDPV). Combined with labeling that they are "not for human consumption", these descriptions are an attempt to skirt the Federal Analog Act which forbids drugs that are “substantially similar” to already classified drugs from being sold for human use.
Some research chemicals are structural analogues of tryptamines or phenethylamines but there are also many other completely unrelated chemicals that can be considered part of the group. Psychoactivity or other pharmaceutical properties of these compounds might not be predictable based strictly upon structural examination. Many of the substances have common effects whilst structurally different and vice versa due to SAR paradox. As a result of no real official naming for some of these compounds, as well as regional naming, this can all lead to potentially hazardous mix ups for users. The following list is not exhaustive.
- α-methylfentanyl, "China White"
- Parafluorofentanyl, 4-Fluorofentanyl
- Desmethylprodine, MPPP, especially infamous due to an impurity in some batches called MPTP, which caused permanent Parkinsonism with a single use
A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception. Psychedelics tend to affect and explore the mind in ways that result in the experience being qualitatively different from those of ordinary consciousness. The psychedelic experience is often compared to non-ordinary forms of consciousness such as trance, meditation, yoga, religious ecstasy, dreaming and even near-death experiences.
- 4-AcO-DALT, Dalcetin
- 4-AcO-DET, Ethacetin
- 4-AcO-DMT, Psilacetin
- 4-AcO-DPT, Depracetin
- 4-AcO-DiPT, Ipracetin
- 4-AcO-MET, Metacetin
- 4-AcO-MiPT, Mipracetin
- 4-HO-DALT, Dalocin
- 4-HO-DET, Ethocin
- 4-HO-DPT, Deprocin
- 4-HO-DiPT, Iprocin
- 4-HO-MET, Metocin
- 4-HO-MiPT, Miprocin
- 4-HO-MPT, Meprocin
- 4-HO-MPMI, Lucigenol
- 4-PO-DET, Ethocybin, CEY-19
- 5-MeO-DiPT, Foxy
- 5-MeO-MiPT, Moxy
- 5-MeO-TMT, Indapex
- DALT, Diallyltryptamine
- DET, Diethyltryptamine
- DiPT, Diisopropyltryptamine
- DPT, Dipropyltryptamine
- EiPT, Ethylisopropyltryptamine
- MET, Methylethyltryptamine
- MiPT, Methylisopropyltryptamine
- Escaline, "E"
- Proscaline, "P"
- Isoproscaline, "IP"
- Allylescaline, "AL"
- Methallylescaline, "MAL"
2C-x class of psychedelics are 2,5-dimethoxy-phenethylamine derivatives.
- BOB, β-Methoxy-2C-B
- 2C-D, 2C-M
- BOD, β-Methoxy-2C-D
- 2C-E, "Europa"
- 2C-iP, "Jelena"
The DOx family of psychedelics are also known as "substituted amphetamines" as they contain the amphetamine backbone but are substituted on the benzene ring. This gives rise to serotonin agonists similar to the 2C-X class but more resistant to elimination in the body.
- 25B-NBOMe, "Nova", Cimbi-36
- 25C-NBOMe, "Pandora", Cimbi-82
- 25D-NBOMe, "Divination"
- 25I-NBOMe, "Solaris", Cimbi-5
- 25I-NBOH, Cimbi-27
- 25I-NBF, Cimbi-21
- 25I-NBMD, Cimbi-29
Dissociatives are a class of hallucinogens which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression, analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.
Arylcyclohexylamines are a class of NMDA receptor antagonists that confers anesthetic, anticonvulsant, neuroprotective, and dissociative effects.
- 4-MeO-PCP, Methoxydine
- Eticyclidine, PCE, CI-400
- E-Methoxetamine, 3-MeO-2'-OxO-PCM, Methoxmetamine, MXM, 3-MeO-Deschloro-Ketamine
- Methoxetamine, 3-MeO-2'-Oxo-PCE
- 3-MeO-PCE, Methoxieticyclidine
- Rolicyclidine, PCPy
- Tenocyclidine, TCP
- Methoxyketamine, 2-MeO-2-Deschloroketamine
Diarylethylamine began to appear on grey markets only as recently as 2013 and include:
Piperazine containing designer drugs have effects similar to MDMA ("ecstasy"). This class of drugs are are mimics of serotonin that activate 5-HT receptor subtypes that release norepinephrine and dopamine.
- 3-Chlorophenylpiperazine, meta-Chlorophenylpiperazine, mCPP
- 4-Methoxyphenylpiperazine, para-Methoxyphenylpiperazine, MeOPP, pMPP, 4-MPP, Paraperazine
- 4-Fluorophenylpiperazine, para-Fluorophenylpiperazine, pFPP, 4-FPP, Fluoperazine, Flipiperazine
- Trifluoromethylphenylpiperazine, TFMPP
- Benzylpiperazine, BZP
- Dibenzylpiperazine, DBZP
- Methylbenzylpiperazine, MBZP
- Methylenedioxybenzylpiperazine, MDBZP, Piperonylpiperazine
Empathogens are a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA . Users of empathogens say the drugs often produce feelings of empathy, love, and emotional closeness to others.
Substituted methylenedioxyphenethylamines (MDxx) are a large chemical class of derivatives of the phenethylamines, which includes many psychoactive drugs that act as entactogens, psychedelics, and/or stimulants, as well as entheogens.
- MDEA, Methylenedioxyethylamphetamine, MDE, "Eve"
- Ethylone, βk-MDEA
- EBDB, Ethylbenzodioxolylbutanamine
- Eutylone, βk-EBDB
- MBDB, Methylbenzodioxylbutanamine, "Eden"
- Butylone, βk-MBDB
- Dibutylone, βk-DMBDB
- MBDP, Methylbenzodioxylpentanamine
- Pentylone, βk-MBDP
- Dipentylone, βk-DMBDP
- Methylone, βk-MDMA
- Dimethylone, βk-MDDMA, "M11"
- FLEA, Methylenedioxyhydroxymethamphetamine, MDHMA
- EDMA, Ethylenedioxymethylamphetamine
- EFLEA, prodrug of EDMA
- Difluoromethylenedioxyamphetamine, DiFMDA
- Methylenedioxyhydroxyamphetamine, MDOH
- MMDA, 3-Methoxy-MDA
- βk-N-Methyl-MMDA, "2-AIMP"
- Lophophine, MMDPEA, 3-MeO-MDPEA
- MMDA-2, 2-MeO-MDA
Benzofurans are similar in structure to MD(M)A but differ in that the methylenedioxy groups have been modified, removing one of the two oxygens in the methylenedioxy ring to render a benzofuran ring.
Miscellaneous polycyclic phenethylamines
Only one non-tryptamine indole has been sold, 5-API. It shows strong MAOI activity.
- 5-API, 5-IT, PAL-571
- αET, α-Ethyltryptamine, "Monase"
- 5-MeO-αET, α,O-Diethylserotonin
- αMT, α-Methyltryptamine, "Indopan"
- 5-MeO-αMT, α,O-Dimethylserotonin
Amphetaminess are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.
- MMA, 3-Methoxy-4-Methylamphetamine
- 4-FA, 4-Fluoroamphetamine
- 4-MTA, 4-Methylthioamphetamine, a highly dangerous MAO-A inhibitor
- Naphthylaminopropane, PAL-287
- 4-Methoxyamphetamine, para-Methoxyamphetamine, PMA, 4-MeoA, "Death", a highly dangerous amphetamine derivative responsible for many accidental deaths
- 4-Methoxymethamphetamine, para-Methoxymethamphetamine, PMMA, 4-MeoMA
Stimulants produce a variety of different kinds of effects by enhancing the activity of the central and peripheral nervous systems. Common effects, which vary depending on the substance and dosage in question, may include enhanced alertness, awareness, wakefulness, endurance, productivity, and motivation, increased arousal, locomotion, heart rate, and blood pressure, and the perception of a diminished requirement for food and sleep.
Amphetaminess are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.
- 4-BA, 4-Bromoamphetamine, PBA, highly neurotoxic
- 4-CA, 4-Chloroamphetamine, PCA, highly neurotoxic
- 2-FA, 2-Fluoroamphetamine
- 3-FA, 3-Fluoroamphetamine
- 2-FMA, 2-Fluoromethamphetamine
- 3-FMA, 3-Fluoromethamphetamine
- 4-FMA, 4-Fluoromethamphetamine
Cathinones include some stimulants and entactogens, which are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions.
- 4-Bromoethcathinone, 4-BEC
- 3-Methylethcathinone, 3-MEC
- 4-Methylethcathinone, 4-MEC
- N,N-Diethyl-4-Methcathinone, N,N-DEMC
- 4-Ethylmethcathinone, 4-EMC
- 4-Bromomethcathinone, 4-Bromomethcathinone, 4-BMC, Brephedrone
- 3-Chloromethcathinone, 3-CMC, Metaclephedrone
- 4-Chloromethcathinone, 4-CMC, Clephedrone
- 2-Fluoromethcathinone, 2-FMC
- 3-Fluoromethcathinone, 3-FMC
- 4-Fluoromethcathinone, Flephedrone, 4-FMC
- 3-Methoxymethcathinone, 3-MeOMC
- 4-Methoxymethcathinone, Methedrone, βk-PMMA, 4-Methoxyephedrone, 4-MeoMC
- 2-Methylmethcathinone, 2-MMC
- 3-Methylmethcathinone, 3-MMC
- 4-Methylmethcathinone, Mephedrone, 4-MMC, 4-Methylephedrone, "MCAT"
- 3,4-Dimethylmethcathinone, 3,4-DMMC
- Benzedrone, 4-MBC
- Buphedrone, α-Methylamino-Butyrophenone, MABP
- 4-Methylbuphedrone, 4-MeMABP, BZ-6378
- N-Ethylbuphedrone, NEB
- Pentedrone, α-Methylamino-Valerophenone, MAVP, PD
- α-Ethylaminopentiophenone, EAPP
- 4-Methyl-α-Ethylaminopentiophenone, 4-MEAPP, N-Ethyl-4-Methylpentedrone
- 4-Fluoropentedrone, 4-FPD
- 4-Methylpentedrone, 4-MPD
- βk-IVP, Indanyl-N-Ethyl-Pentedrone
- DL-4662, Dimethoxyethylpentedrone
- NPP, α-Isopropylamino-Valerophenone, iPAVP
- 4-Fluoro-Piperidinopentiophenone, 4F-PPP
Pyrrolidines and Pyrrolidinophenones
- Diphenylprolinol, D2PM
- 2-Diphenylmethylpyrrolidine, Desoxy-D2PM
- α-Pyrrolidinopropiophenone, α-PPP
- 3',4'-Methylenedioxy-α-pyrrolidinopropiophenone, MDPPP
- 4'-Methoxy-α-pyrrolidinopropiophenone, MOPPP
- 4'-Methyl-α-pyrrolidinopropiophenone, 4-MePPP, MPPP, MαPPP
- 4'-Methyl-α-pyrrolidinohexiophenone, MPHP, PV-4
- 4'-Methyl-α-pyrrolidinobutiophenone, MPBP
- 3',4'-Methylenedioxy-α-pyrrolidinobutiophenone, MDPBP
- Methylenedioxypyrovalerone, MDPV
- Naphyrone, Naphthylpyrovalerone , O-2482
- α-Pyrrolidinopentiophenone, α-PVP, βk-Prolintane, O-2387, PV-3
- 3,4-Dimethoxy-α-Pyrrolidinopentiophenone, 3,4-DMPV
- 4-Methoxy-α-Pyrrolidinopentiophenone, 4-MeO-α-PVP, 4-MeO-PVP
- 4-Fluoro-Pyrrolidinopentiophenone, 4F-PVP, 4F-α-PVP
- 5-Dihydrobenzofuranpyrovalerone, 5-DBFPV
- α-Pyrrolidinobutiophenone, α-PBP
- 4-Methoxy-Pyrrolidinobutyrophenone, 4-MeO-PBP
- 5-PPDI, Indanyl-α-PBP
- α-Pyrrolidinobutiothiophenone, α-PBT
- α-Pyrrolidinylhexaphenone, α-PHP, PV-7
- 3,4-Dimethoxy-α-PHP, 3,4-DMPH
- Methylenedioxypyrrolidinohexiophenone, MDPHP
- α-Pyrrolidinopentiothiophenone, α-PVT
- α-Pyrrolidinoheptanophenone, PV-8, α-PHPP
- 4-Fluoro-α-Pyrrolidinoheptanophenone, 4F-PV8, 4F-α-PHPP
- α-Pyrrolidinooctanophenone, PV-9, α-POP
- 4-Fluoro-α-Pyrrolidinooctanophenone, 4F-PV-9, 4F-α-POP
- 4-Methoxy-α-Pyrrolidinooctanophenone, 4-MeO-PV-9, 4-MeO-α-POP
Thiophenes are stimulant drugs which are analogues of amphetamine or cathinone where the phenyl ring has been replaced by thiophene.
Tropanes and Piperidines
Tropane alkaloids occur in plants of the families erythroxylaceae (including coca). Piperidine and its derivatives are ubiquitous building blocks in the synthesis of many pharmaceuticals and fine chemicals.
- 4'-Fluorococaine, 4'-FC
- Diclofensine, Ro 8-4650
- Dichloropane, RTI-111, O-401
- Dimethocaine, Larocaine
- Nitracaine, 4-Nitro-Dimethocaine
- 3,4-Dichloromethylphenidate, 3,4-CTMP
- Ethylphenidate, EPH
- Isopropylphenidate, IPH
- HDMP-28, Methylnaphthidate
- Troparil, WIN 35,065-2, β-CPT
- Desoxypipradrol, 2-DPMP , 2-Diphenylmethylpiperidine
Oxazolidines are a five-membered ring compounds consisting of three carbons, a nitrogen, and an oxygen. The oxygen and NH are the 1 and 3 positions, respectively. In oxazolidine derivatives, there is always a carbon between the oxygen and the nitrogen.
Cyclopropane is a cycloalkane molecule with the molecular formula C3H6, consisting of three carbon atoms linked to each other to form a ring, with each carbon atom bearing two hydrogen atoms resulting in D3h molecular symmetry. Cyclopropane rings are found in numerous biomolecules and pharmaceutical drugs.
Sedatives are substances that induces sedation by reducing irritability or excitement. At higher doses they may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect. Sedatives can be misused to produce an overly-calming effect. In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness and even death.
- 1,4-Butanediol, a prodrug to GHB
- 2-Methyl-2-butanol, 2M2B, tert-Amyl alcohol, a more potent analogue of ethanol
- GBL, Gamma-butyrolactone, both a precursor to and prodrug for GHB
- GHV, Gamma-hydroxyvaleric acid (4-Methyl-GHB)
- GVL, Gamma-valerolactone, a prodrug for GHV
- Etaqualone, 2-Ethyl-Methaqualone
- Mecloqualone, 2-Chloro-Methaqualone
- Mebroqualone, 2-Bromo-Methaqalone, "MBQ"
- Methylmethaqualone, "MMQ"
- Diclazepam, 2-Chloro-Diazepam
- Deschloroetizolam, "Etizolam-2"
- Nifoxipam, 3-HO-Desmethyl-Flunitrazepam
Agonists of the central cannabinoid receptor type 1 mimic the behavioral effects of cannabis.
Indazole containing cannabinoid receptor agonists include:
- APINACA, AKB48
Indole containing cannabinoid receptor agonists include:
- APICA, SDB-001, 2NE1
- STS-135, 5F-APICA
- MN-24, NNEI
- Org 28611
- XLR-11, 5F-UR-144
Androgenic anabolic steroids have approved medical uses as well as used illicitly as performance-enhancing drugs to build muscle mass and strength. Anabolic steroids that have been designed to evade detection in sport doping tests are known as "designer steroids". They can be divided into:
- 4-Chlorodehydromethyltestosterone, Turinabol
- Clostebol, 4-Chloro-Testosterone
- Fluoxymesterone, Halotestin
- Methandrostenolone, Dianabol
- Methyltestosterone, Methyltestosterone
- Dihydrotestosterone, DHT
- 1-Testosterone, Dihydroboldenone
- Desoxymethyltestosterone, Madol, "DMT"
- Drostanolone, Masteron
- Mesterolone, Proviron
- Metenolone enanthate, Primobolan
- Methasterone, Superdrol, Methasteron, Methyldrostanolone
- Methyl-1-testosterone, M1T
- Oxandrolone, Anavar
- Oxymetholone, Anadrol
- Prostanozol, prodrug for Stanozolol
- Stanozolol, Winstrol
Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor ligands. They are intended to maintain the desirable muscle building effects of anabolic steroids while reducing undesirable androgenic actions (e.g., increased risk of prostate cancer). SARMs that are more selective in their action potentially could be used for a wider range clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.
Growth hormone secretagogue receptor agonists
Agonists of the growth hormone secretagogue receptor regulate energy homeostasis and body weight.
- Bremelanotide, PT-141: Used to enhance libido.
- Delta sleep - inducing peptide
- Melanotan Used to increase melanin production.
- Melanotan II A cyclic analogue of Melanotan which has greatly increased potency.
PDE5 inhibitors are typically used to treat erectile dysfunction and improve sexual stamina.
- cf. Drug design
- Controlled Substances Act
- Controlled Substance Analogue Enforcement of 1986
- Operation Web Tryp
- Pharmaceutical company
- Wohlfarth A, Weinmann W (2010). "Bioanalysis of new designer drugs". Bioanalysis 2 (5): 965–79. doi:10.4155/bio.10.32. PMID 21083227.
- "New Psychoactive Substances (NPS)". Drug War Facts. Common Sense for Drug Policy. "The term 'new psychoactive substances' had been legally defined by the European Union as a new narcotic or psychotropic drug, in pure form or in a preparation, that is not scheduled under the Single Convention on Narcotic Drugs of 1961 or the Convention on Psychotropic Substances of 1971, but which may pose a public health threat comparable to that posed by substances listed in those conventions (Council of the European Union decision 2005/387/JHA)."
- Teale P, Scarth J, Hudson S (2012). "Impact of the emergence of designer drugs upon sports doping testing". Bioanalysis 4 (1): 71–88. doi:10.4155/bio.11.291. PMID 22191595.
- Carroll FI, Lewin AH, Mascarella SW, Seltzman HH, Reddy PA (2012). "Designer drugs: a medicinal chemistry perspective". Ann. N. Y. Acad. Sci. 1248: 18–38. doi:10.1111/j.1749-6632.2011.06199.x. PMID 22092008.
- Reneman L (2003). "Designer drugs: how dangerous are they?". J. Neural Transm. Suppl. (66): 61–83. PMID 14582803.
- Buchanan JF, Brown CR (1988). "Designer drugs. A problem in clinical toxicology". Medical Toxicology and Adverse Drug Experience 3 (1): 1–17. doi:10.1007/bf03259928. PMID 3285124.
- "Esters of Morphine". UNODC Bulletin on Narcotics (2): 36–38. 1953.
- Brecher, Edward M. (1972). The Consumers Union Report on Licit and Illicit Drugs. Consumer Reports Magazine.
- Snyder SH, Faillace L, Hollister L (1967). "2,5-dimethoxy-4-methyl-amphetamine (STP): A new hallucinogenic drug". Science 158 (3801): 669–70. doi:10.1126/science.158.3801.669. PMID 4860952.
- Donald A. Cooper. Future Synthetic Drugs of Abuse. Drug Enforcement Administration, McLean, Virginia
- Fahn S (1996). "The Case of the Frozen Addicts: How the Solution of an Extraordinary Medical Mystery Spawned a Revolution in the Understanding and Treatment of Parkinson's Disease". The New England Journal of Medicine 335 (26): 2002. doi:10.1056/NEJM199612263352618.
- Henderson GL (1988). "Designer Drugs: Past History and Future Prospects". Journal of Forensic Sciences 33 (2): 569–575. PMID 3286815.
- TheDEA.org: The History of MDMA
- Philip Jenkins. Synthetic Panics: The Symbolic Politics of Designer Drugs. NYU Press 1999. ISBN 978-0-8147-4244-0
- Cole MD, Lea C, Oxley N (2002). "4-Bromo-2,5-dimethoxyphenethylamine (2C-B): A review of the public domain literature". Science & justice : journal of the Forensic Science Society 42 (4): 223–4. doi:10.1016/S1355-0306(02)71832-7. PMID 12632938.
- de Boer D, Bosman I (2004). "A new trend in drugs-of-abuse; the 2C-series of phenethylamine designer drugs". Pharmacy world & science : PWS 26 (2): 110–3. doi:10.1023/b:phar.0000018600.03664.36. PMID 15085947.
- Uchiyama N, Kikura-Hanajiri R, Kawahara N, Goda Y (2008). "Analysis of designer drugs detected in the products purchased in fiscal year 2006". Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 128 (10): 1499–505. doi:10.1248/yakushi.128.1499. PMID 18827471.
- Malvey TC, Armsey TD (2005). "Tetrahydrogestrinone: The discovery of a designer steroid". Current sports medicine reports 4 (4): 227–30. doi:10.1097/01.csmr.0000306213.87433.11. PMID 16004834.
- Reepmeyer JC, Woodruff JT, d'Avignon DA (2007). "Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement". Journal of pharmaceutical and biomedical analysis 43 (5): 1615–21. doi:10.1016/j.jpba.2006.11.037. PMID 17207601.
- Venhuis BJ, Blok-Tip L, de Kaste D (2008). "Designer drugs in herbal aphrodisiacs". Forensic Science International 177 (2–3): e25–7. doi:10.1016/j.forsciint.2007.11.007. PMID 18178354.
- Spice enthält chemischen Wirkstoff (German)
- Evans-Brown M, Dawson RT, Chandler M, McVeigh J (2009). "Use of melanotan I and II in the general population". BMJ 338: b566. doi:10.1136/bmj.b566. PMID 19224885.
- "EU struggles to curb hard drugs". BBC News. 5 November 2009.
- "2009 Annual report: the state of the drugs problem in Europe.". Lisbon: European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Retrieved November 2009.
- Measham, F.; Moore, K.; Newcombe, R.; Smith), Z. (12 March 2010). "Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition". Drugs and Alcohol Today 10 (1): 14–21. doi:10.5042/daat.2010.0123.(subscription required)
- Power, Mike (2014-10-31). "Drugs unlimited: how I created my very own legal high". The Guardian. Retrieved 7 August 2014.
- "EMCDDA–Europol 2013 Annual Report on the information exchange, risk assessment and control of new psychoactive substances (implementation of Council Decision 2005/387/JHA)". EMCDDA. July 2014. Retrieved 8 August 2014.
- Andreasen MF, Telving R, Birkler RI, Schumacher B, Johannsen M (2009). "A fatal poisoning involving Bromo-Dragonfly". Forensic Science International 183 (1–3): 91–6. doi:10.1016/j.forsciint.2008.11.001. PMID 19091499.
- Lindigkeit R, Boehme A, Eiserloh I, Luebbecke M, Wiggermann M, Ernst L, Beuerle T (2009). "Spice: A never ending story?". Forensic Science International 191 (1–3): 58–63. doi:10.1016/j.forsciint.2009.06.008. PMID 19589652.
- Nu beslagtar svenska tullen lagliga droger, Sveriges Radio, 23 April 2011
- DRUG MISUSE AND TRAFFICKING ACT 1985 - SCHEDULE 1
- Commonwealth Criminal Code Act 1995 s 314.1(2)
- "Consideration of the cathinones". Advisory Council on the Misuse of Drugs. 31 March 2010. p. 25. Retrieved 1 April 2010.
- "Police warning over 'bubble' drug". BBC News. 20 November 2009. Retrieved 2009-11-27.
- Reed, Jim (13 January 2010). "Clubbers are 'turning to new legal high mephedrone'". BBC News. Retrieved 2010-07-04.
- Victoria Cumbow (2011-02-06). "Synthetic form of cocaine and methamphetamine being packaged as bath salts". The Huntsville Times. Retrieved 2011-02-10.
- "Reports: Miami 'zombie' attacker may have been using 'bath salts'". CNN. May 29, 2012.
- Abby Goodnough and Katie Zezima (2011-07-16). "An Alarming New Stimulant, Legal in Many States". New York Times. Retrieved 2012-01-15.
- "EMCDDA–Europol 2012 Annual Report on the implementation of Council Decision 2005/387/JHA (New drugs in Europe, 2012)". EMCDDA. May 2013. Retrieved 8 August 2014.
- "EMCDDA–Europol 2011 Annual Report on the (information exchange, risk assessment and control of new psychoactive substances) implementation of Council Decision 2005/387/JHA". EMCDDA. April 2012. Retrieved 8 August 2014.
- "EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA". EMCDDA. May 2011. Retrieved 8 August 2014.
- Shimizu E, Watanabe H, Kojima T, Hagiwara H, Fujisaki M, Miyatake R, Hashimoto K, Iyo M. Combined intoxication with methylone and 5-MeO-MIPT. Progress in Neuropsychopharmacology and Biological Psychiatry. 2007 Jan 30;31(1):288-91. PMID 16876302
- Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ (December 1979). "Chronic Parkinsonism secondary to intravenous injection of meperidine analogues". Psychiatry Research 1 (3): 249–54. doi:10.1016/0165-1781(79)90006-4. PMID 298352.
- Wallis, Claudia (2001-06-24). "Surprising Clue to Parkinson's - TIME". Time. Retrieved 2010-05-01.
- Uchiyama N, Miyazawa N, Kawamura M, Kikura-Hanajiri R, Goda Y (2010). "[Analysis of newly distributed designer drugs detected in the products purchased in fiscal year 2008]". Yakugaku Zasshi (in Japanese) 130 (2): 263–70. doi:10.1248/yakushi.130.263. PMID 20118651.
- "C30-NBOMe". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- Morris H, Wallach J (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis 6 (7–8): 614–632. doi:10.1002/dta.1620. PMID 24678061.
- King LA. New drugs coming our way - what are they and how do we detect them? EMCDDA Conference, Lisbon, 6–8 May 2009
- Dargan, P. I.; Button, J.; Hawkins, L.; Archer, J. R. H.; Ovaska, H.; Lidder, S.; Ramsey, J.; Holt, D. W.; Wood, D. M. (2008). "Detection of the pharmaceutical agent glaucine as a recreational drug". European Journal of Clinical Pharmacology 64 (5): 553–4. doi:10.1007/s00228-007-0451-9. PMID 18204834.
- "Dimethylone". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- Uchiyama N, Matsuda S, Kawamura M, Shimokawa Y, Kikura-Hanajiri R, Aritake K, Urade Y, Goda Y (2013). "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products". Forensic Science International 243: 1–13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262.
- "3-MEC". SWGDRUG. 2013. Retrieved 19 August 2014.
- "2-FMC". SWGDRUG. 2013. Retrieved 19 August 2014.
- "2-MMC". SWGDRUG. 2013. Retrieved 19 August 2014.
- "4-Methylbuphedrone". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "PV-8". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- Markowitz JS, Zhu HJ, Patrick KS (2013). "Isopropylphenidate: An Ester Homolog of Methylphenidate with Sustained and Selective Dopaminergic Activity and Reduced Drug Interaction Liability". Journal of Child and Adolescent Psychopharmacology 23 (10): 648–654. doi:10.1089/cap.2013.0074. PMID 24261661.
- John S. Markowitz, Kennerly S. Patrick, Haojie Zhu (Sep 27, 2012). "Patent US20120245201 - Isopropylphenidate for Treatment of Attention-Deficit/Hyperactivity Disorder and Fatigue-Related Disorders and Conditions". Retrieved 15 August 2014.
- "EG-018 \ Cayman Chemical Item Number 15533". Cayman Chemical. Retrieved 9 August 2014.
- "5F-AB-PINACA". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- Uchiyama N, Shimokawa Y, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y (2014). "Two new synthetic cannabinoids, AM-2201 benzimidazole analog (FUBIMINA) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM), and three phenethylamine derivatives, 25H-NBOMe 3,4,5-trimethoxybenzyl analog, 25B-NBOMe, and 2C-N-NBOMe, identified in illegal products". Forensic Toxicology 32 (1): 105–115. doi:10.1007/s11419-013-0217-2.
- "THJ-018". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "THJ-2201". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "5F-ADB-PINACA". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "SDB-005". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "5F-SDB-005". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "AMB". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "5F-AMB". Forendex. Southern Association of Forensic Scientists. Retrieved 12 August 2014.
- "MN-18". Forendex. Southern Association of Forensic Scientists. Retrieved 12 August 2014.
- "5F-MN-18". Forendex. Southern Association of Forensic Scientists. Retrieved 12 August 2014.
- "5F-SDB-006". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "MN-24". Forendex. Southern Association of Forensic Scientists. Retrieved 14 August 2014.
- "5F-MN-24". Forendex. Southern Association of Forensic Scientists. Retrieved 14 August 2014.
- "FUB-144". Forendex. Southern Association of Forensic Scientists. Retrieved 14 August 2014.
- "FUB-PB-22". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- "FDU-PB-22". Forendex. Southern Association of Forensic Scientists. Retrieved 13 August 2014.
- Kazlauskas R (2010). "Designer steroids". Handb Exp Pharmacol 195: 155–85. doi:10.1007/978-3-540-79088-4_7. PMID 20020364.
- Abushareeda W, Fragkaki A, Vonaparti A, Angelis Y, Tsivou M, Saad K, Kraiem S, Lyris E, Alsayrafi M, Georgakopoulos C (2014). "Advances in the detection of designer steroids in anti-doping". Bioanalysis 6 (6): 881–96. doi:10.4155/bio.14.9. PMID 24702116.
- Zhang X, Sui Z (2013). "Deciphering the selective androgen receptor modulators paradigm". Expert Opin Drug Discov 8 (2): 191–218. doi:10.1517/17460441.2013.741582. PMID 23231475.
- Zhang X, Li X, Allan GF, Sbriscia T, Linton O, Lundeen SG, Sui Z (January 2007). "Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators". Bioorganic & Medicinal Chemistry Letters 17 (2): 439–43. doi:10.1016/j.bmcl.2006.10.035. PMID 17079140.
- Allan GF, Tannenbaum P, Sbriscia T, Linton O, Lai MT, Haynes-Johnson D, Bhattacharjee S, Zhang X, Sui Z, Lundeen SG (2007). "A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats". Endocrine 32 (1): 41–51. doi:10.1007/s12020-007-9005-2. PMID 17992601.
- Basaria S, Collins L, Dillon EL, Orwoll K, Storer TW, Miciek R, Ulloor J, Zhang A, Eder R, Zientek H, Gordon G, Kazmi S, Sheffield-Moore M, Bhasin S (2013). "The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men". J. Gerontol. A Biol. Sci. Med. Sci. 68 (1): 87–95. doi:10.1093/gerona/gls078. PMC 4111291. PMID 22459616.
- Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). "Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression". Biol. Pharm. Bull. 36 (9): 1460–5. doi:10.1248/bpb.34.318. PMID 23995658.
- "Public Notification: "RigiRx Plus" Contains Undeclared Drug Ingredient". US FDA. 20 April 2012. Retrieved 15 August 2014.
- Venhuis BJ, Zomer G, Hamzink M, Meiring HD, Aubin Y, de Kaste D (2011). "The identification of a nitrosated prodrug of the PDE-5 inhibitor aildenafil in a dietary supplement: a Viagra with a pop". J Pharm Biomed Anal 54 (4): 735–41. doi:10.1016/j.jpba.2010.11.020. PMID 21145686.
- Substances and classifications table (31/10/2008) – European Legal Database on Drugs raport on all substances controlled in at least one EU country in XLS format
- Research Chemical FAQ on Erowid
- A comprehensive guide to CNS compounds and products
- Knowledge base on harm reduction regarding consumption of designer drugs
- National Institute on Drug Abuse: "NIDA for Teens: Bath Salts".