Tolterodine

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(Redirected from Detrol)


Tolterodine
Systematic (IUPAC) name
2-[(1S)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol
Identifiers
CAS number	124937-51-5
ATC code	G04BD07
PubChem	60774
DrugBank	APRD00146
Chemical data
Formula	C₂₂H₃₁N O
Mol. mass	325.488 g/mol
Pharmacokinetic data
Bioavailability	77%
Protein binding	Approximately 96.3%.
Metabolism	?
Half life	1.9-3.7 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. It is sold under the trade names Detrol and Detrusitol.

[edit] Pharmacology

Tolterodine acts on M1, M2, M3, M4 and M5 subtypes of muscarinic receptors whereas modern antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective. It is marketed and manufactured by Pfizer.

Tolterodine, although it acts on all types of receptors, has fewer side effects than other antimuscarinics eg. oxybutynin (M3 and M1 selective, but more so in the parotid than in the bladder) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects.