The first written account of the colic comes from 1655. Symptoms began with severe abdominal pains and the condition was occasionally fatal. Cider is the traditional drink of Devonians, and the connection between the colic and cider drinking had been observed for many years. This was commonly attributed to the acidity of the beverage.
William Musgrave's publication De arthritide symptomatica (2nd edn, 1715) included the first scientific description of "Devonshire colic" – it was later referred to by John Huxham and Sir George Baker.
However, the precise cause was not discovered until the 1760s when Dr George Baker put forwards the hypothesis that poisoning from lead in cider was to blame. He observed that the symptoms of the colic were similar to those of lead poisoning. He pointed out that lead was used in the cider making process both as a component of the cider presses and in the form of lead shot which was used to clean them. He also conducted chemical tests to demonstrate the presence of lead in Devon apple juice.
The publication of his results met with some hostile reaction from cider manufacturers, keen to defend their product.
Once Baker's conclusions became accepted and the elimination of lead from the cider presses was undertaken, the colic declined. By 1818, Baker's son reported that it was "hardly known to exist" in Devon.