|Systematic (IUPAC) name|
|Mol. mass||309.40 g/mol|
|(what is this?)|
Dexoxadrol (Dioxadrol) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol, were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations.
W. R. Hardie, J. Hidalgo and I. F. Halvorstadt, J. Med. Chem., 9, 127 (1966).
- Sax, M.; Wünsch, B. (2006). "Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity". Current Topics in Medicinal Chemistry 6 (7): 723–732. doi:10.2174/156802606776894483. PMID 16719812.
- Aepkers, M.; Wünsch, B. (2005). "Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol". Bioorganic and Medicinal Chemistry 13 (24): 6836–6849. doi:10.1016/j.bmc.2005.07.030. PMID 16169732.
- Hardie, W. R. (1966). "4-(2-Piperidyl)-1,3-dioxolanes with Local Anesthetic, Spasmolytic, and Central Nervous System Activity 1". Journal of Medicinal Chemistry 9 (1): 127–136. doi:10.1021/jm00319a030.
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